| 周宪 舒小镭 蒋勇 胡长江 杨仕明 万跃.立体定向适形放疗在早期肝癌治疗中的应用[J].,2015,15(20):3862-3864 |
| 立体定向适形放疗在早期肝癌治疗中的应用 |
| Stereotactic Conformal Radiotherapy in the Treatment ofEarly Hepatocellular Carcinoma |
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| DOI： |
| 中文关键词: 立体定向适形放疗 肝动脉化疗栓塞 肝癌 治疗 |
| 英文关键词: Stereotactic conformal radiotherapy Transcatheter arterial chemoembolization Liver cancer Treatment |
| 基金项目:国家自然科学基金项目（81402034，30900679） |
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| 中文摘要: |
| 目的：探讨立体定向适形放疗对早期肝癌患者临床疗效的影响。方法：回顾性分析我院2008 年5 月~2011 年5 月收治的
190 例早期肝癌患者，按照其治疗方式分为放疗组（n=95）及化疗组（n=95），2 组患者分别接受立体定向适形放疗及肝动脉化疗栓
塞治疗，比较患者的临床疗效。结果：2 组患者治疗前后WBC、RBC、PLT、TBIL、ALT、PT 指标均未见明显变化（P＞0.05）；2 组患
者治疗后AFP、TMD 均显著降低，放疗组降低程度更为明显（P＜0.05）；放疗组总有效率为69.48%，显著高于化疗组的43.16%
（P＜0.05）。2 组患者治疗期间均发生胃肠道反应等并发症，经对症处理后症状消失，均未见其他严重并发症发生；2 组患者1年复
发率、1 年生存率及2年生存率无明显统计学差异（P＞0.05）；放疗组2 年、3 年复发率显著低于对照组，其3 年生存率显著高于化
疗组（P＜ 0.05）。结论：立体定向适形放疗能够有效降低早期肝癌患者AFP 水平，缩小其肿瘤直径，具有良好的临床疗效，且该方
案对患者血液指标、机体状态影响较小，具有良好的安全性，是保障医疗质量、改善患者预后的有效手段。 |
| 英文摘要: |
| Objective:To investigate the effect and clinical outcomes of stereotactic conformal radiotherapy on early
hepatocellular carcinoma.Methods:A retrospective analysis was performed for 190 cases of early HCC patients in our hospital fromMay
2008 to May 2011. The patients were randomly divided into radiotherapy group (n=95) and chemotherapy group (n=95), who were
respectively treated with stereotactic conformal radiotherapy and chemotherapy of hepatic artery embolization. The clinical efficacy was
compared between two groups.Results:There was no significant change before and after treatment in both two groups in the index of
WBC, RBC, PLT, TBIL, ALT, PT index (P>0.05); the level of AFP and TMD was significantly decreased in both two groups, and it was
more obviously in the radiotherapy group (P<0.05); the total effective rate of radiotherapy group was 69.48%, which was significantly
higher than that of 43.16% in the chemotherapy group (P<0.05). During the treatment, the complications including neutropenia,
gastrointestinal reaction were detected in both of two groups and after symptomatic treatment, the symptoms disappeared, and no other
serious complications occurred. There was no significant difference between the two groups in the relapse rate at 1 year and 2 years
survival rate (P>0.05), while the 2 years and 3 years recurrence rate was significantly lower in the radiotherapy group than in control
group and the 3 years survival rate was significantly higher in the radiotherapy group than in chemotherapy group (P<0.05).Conclusion:The stereotactic conformal radiotherapy can effectively decrease the AFP level in patients with early hepatocellular carcinoma, reduce the
tumor diameter. What's more, it has only slight influence on the blood parameters of patients which indicates that stereotactic conformal
radiotherapy has a good clinical efficacy with a high safety, and can contribute to improving the prognosis of patients of liver cancer. |
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