| 周春晶 刘玉凤 李宏宇 李军 孙秀英 杨琼.阿昔洛韦对传染性单核细胞增多患儿CD4+和CD8+的影响[J].,2015,15(20):3865-3868 |
| 阿昔洛韦对传染性单核细胞增多患儿CD4+和CD8+的影响 |
| Influence of Acyclovir on the Level of CD4+, CD8+ in InfectiousMononucleosis in Children |
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| DOI： |
| 中文关键词: 阿昔洛韦 传染性单核细胞增多症 CD4+ CD8+ |
| 英文关键词: Acyclovir Infectious mononucleosis CD4+ CD8+ |
| 基金项目:国家自然科学基金项目（30700758） |
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| 中文摘要: |
| 目的：探究阿昔洛韦对小儿传染性单核细胞增多症CD4+、CD8+的影响。方法：选取我院收治的小儿传染性单核细胞增多症的
患者64 例，随机分为两组。实验组予阿昔洛韦静脉滴注，对照组予利巴韦林静脉滴注。对比两组的临床疗效及CD4+、CD8+和
CD4+/CD8+比值的变化情况。结果：①治疗后两组患儿临床疗效，实验组较对照组显著改善，差异有统计学意义(P＜0.05)。②治疗后
两组患儿退热时间、淋巴结消退时间、异型淋巴细胞消失时间以及住院时间等比较，实验组明显较对照组短，差异有统计学意义
(P＜0.05)。③治疗前，两组患者CD4+、CD8+以及CD4+/CD8+比值无统计学差异（P>0.05）；治疗后，患者CD4+及CD4+/CD8+比值呈现
先升高再降低的趋势，CD8+则呈现下降趋势，与对照组比较，实验组治疗3 天，10 天及1 个月CD4+以及CD8+下降明显，差异具有
统计学意义（P＜0.05）；CD4+/CD8+比值则较对照组升高（P＜0.05）。结论：采用阿昔洛韦能够更好的改善患者临床症状，影响CD4+、
CD8+的变化，使紊乱的免疫系统较快的恢复。 |
| 英文摘要: |
| Objective:To explore the influence of acyclovir on the level of CD4+ and CD8+ in infectious mononucleosis in children.Methods:64 cases from our hospital diagnosed of infectious mononucleosis were selected and randomly divided into two groups, 32
cases in each group. The children in experimental group were administered acyclovir, daily 10 mg/kg, adding to 10% Glucose injection
100 mL, for twice intravenous infusion, 12 days as a treatment course. The control group was treated with ribavirin, daily 10 mg/kg,
adding to 0.9% sodium chloride injection (100 mL), for twice intravenous infusion, and 12 days as a treatment course. The clinical
curative effect before and after treatment, the index of curative effect, the level of CD4+, CD8+ and CD4+/CD8+ ratio on 1st day, 3rd day,
10th day, and 1 month after treatment was compared between two groups.Results:The clinical curative effect of the experimental group
was improved significantly compared with that of the control group after the treatment, and the difference was statistically significant
(P＜0.05); Comparing the therapeutic index after treatment between the two groups, it was significantly shorter in the experimental group
than that of the control group, and the difference was statistically significant (P＜0.05); Before treatment, no significant difference
between the two groups of patients with CD4+, CD8+ and CD4+/CD8+ ratio(P>0.05); after treatment, for the experimental group, CD4+and the
ratio of CD4+/CD8+ was increased firstly and then decreased, while CD8+was decreased; compared to the control group, CD4+ and CD8+was
decreased significantly in the experimental group in 3rd day, 10th day and 1 month with statistical significance differences (P<0.05); the
ratio of CD4+/CD8+ was higher than that of control group with statistically significant difference (P<0.05).Conclusion:Acyclovir can
significantly improve the clinical symptoms in children with infectious mononucleosis with better effect on the changes of CD4+, CD8+,
and make the disorder immune systemrecovery. |
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