| 朱雷 赵志斌 丁孟谣 王炜 张姗齐.丙泊酚与异氟醚麻醉对妇科腹腔镜手术患者血流动力学及应激反应的影响[J].,2015,15(22):4351-4354 |
| 丙泊酚与异氟醚麻醉对妇科腹腔镜手术患者血流动力学及应激反应的影响 |
| Effect of Propofol and Isoflurane on the Stress Hormones and Hemodynamicsof Patients Undergoing Gynecological Laparoscopic Surgery |
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| DOI： |
| 中文关键词: 丙泊酚 异氟醚 腹腔镜手术 应激激素 血流动力学 |
| 英文关键词: Propofol Isoflurane Laparoscope Stress response Hemodynamics |
| 基金项目:江苏省连云港市卫生局课题(1401)；国家自然科学基金项目(81100558) |
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| 中文摘要: |
| 目的：探究丙泊酚与异氟醚麻醉对接受妇科腹腔镜手术的患者应激激素以及血流动力学的影响。方法：选取我院妇科收治的
需要进行腹腔镜手术的患者90 例，根据麻醉用药不同，将其分为丙泊酚组、异氟醚组及实验组，每组各30 例。观测患者不同时段
去甲肾上腺素(NE)、肾上腺素(E)、皮质醇(COS)的浓度及心率、平均动脉压、呼吸频率、血氧饱和度等血流动力学参数的变化情况。
结果：三组患者麻醉前及气腹20 min 的去甲肾上腺素、肾上腺素以及皮质醇含量比较均无显著差异(P＞0.05)；气腹前，实验组患
者去甲肾上腺素含量显著低于丙泊酚组及异氟醚组(P＜0.05)；放气10 min，实验组患者肾上腺水平显著高于丙泊酚组及异氟醚
组(P＜0.05)；三组患者麻醉前及气腹前的心率、平均动脉压、呼吸以及血氧饱和度比较均无显著差异(P＞0.05)；气腹20 min，实验
组患者的心率、平均动脉压、呼吸显著优于丙泊酚组及异氟醚组(P＜0.05)；术后放气10 min，实验组患者的心率、平均动脉压、呼
吸显著优于丙泊酚组及异氟醚组(P＜0.05)；实验组患者术后出现恶心、呕吐等症状显著优于丙泊酚组及异氟醚组(P＜0.05)。结论：
丙泊酚复合异氟醚可有效改善接受妇科腹腔镜手术的患者麻醉期间的应激反应和血流动力学，患者术后恶心、呕吐等不良反应
少，值得推广使用。 |
| 英文摘要: |
| Objective:To investigate the effect of propofol and isoflurane on the stress hormones and hemodynamics of patients
undergoing gynecological laparoscopic surgery.Methods:90 patients undergoing gynecological laparoscopic operation in our hospital
were selected and divided into propofol group, isoflurane group and experimental group according to different anesthesia, 30 cases in
each group. The changes of norepinephrine (NE), epinephrine (E), cortisol (COS) concentration and heart rate, mean arterial pressure,
respiratory rate, oxygen saturation as well as other hemodynamic parameters were observed at different time points.Results:Three
groups of patients before anesthesia and pneumoperitoneum 20 min norepinephrine, epinephrine, and cortisol levels compare had no
significant difference (P > 0.05); Norepinephrine levels before pneumoperitoneum, the experimental group patients was significantly
lower than propofol and isoflurane group (P < 0.05); Deflated 10 min, adrenal experimental group patients were significantly higher than
that of propofol and isoflurane group (P < 0.05); Three groups of patients before anesthesia and pneumoperitoneum in front of the heart
rate, mean arterial pressure, respiration and blood oxygen saturation is had no significant difference (P > 0.05); Pneumoperitoneum 20
min, the experimental group the patient's heart rate, mean arterial pressure, and breathing was significantly better than that of propofol
and isoflurane group (P < 0.05); Postoperative deflated 10 min, the experimental group the patient's heart rate, mean arterial pressure, and
breathing significantly better than that of propofol and isoflurane group (P < 0.05); Experimental group patients postoperative symptoms
such as nausea, vomiting, significantly better than that of propofol and isoflurane group (P < 0.05).Conclusion:Propofol combined with
isoflurane could effectively improve the stress response and hemodynamics of patients undergoing gynecological laparoscopic surgery
and had few postoperative nausea, vomiting and other adverse reactions, which was worthy of clinical application. |
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