| 徐芳 马明 艾民 张玲 刘虹颖 常亚娟.痰湿体质PCOS 临床特征及T 淋巴细胞亚群分布特征分析[J].,2015,15(23):4562-4565 |
| 痰湿体质PCOS 临床特征及T 淋巴细胞亚群分布特征分析 |
| Analysis of the Clinical Features and T Lymphocyte SubsetsDistribution on PhlegmDampness Polycystic Ovary Syndrome Patients |
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| DOI： |
| 中文关键词: 多囊卵巢综合征 痰湿体质 临床特征 T 淋巴细胞亚群 |
| 英文关键词: Polycystic Ovary syndrome Phlegmdampness constitution Clinical features T lymphocyte subsets |
| 基金项目:教育部春晖计划项目（Z2010030)；国家中医药管理局国家中医临床研究基地业务建设科研专项课题（JDZX2012039）；
教育部" 春晖计划" 合作科研项目（Z2010013）；教育部" 春晖计划"合作科研项目(教育部Z2010038) |
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| 中文摘要: |
| 目的：探讨痰湿体质多囊卵巢综合征患者临床特征及T 淋巴细胞亚群分布特征。方法：根据PCOS鹿特丹诊断标准和王琦教
授痰湿体质的判定标准，选择痰湿体质PCOS 患者、非痰湿体质PCOS患者各30 例，正常对照组15 例进行性激素和糖脂代谢
指标检测和T 淋巴细胞亚群检测，明确痰湿体质PCOS患者临床特征及T 淋巴细胞亚群的分布特征。结果：三组在年龄和体重指
数上无差异，具有可比性；痰湿体质PCOS 与非痰湿体质PCOS 在LH、T、30 min INS、120 min INS、CHO、LDL 水平明显高于对照
组，具有统计学意义（P<0.05）；痰湿体质组OGTT 血糖水平、CHO、LDL、IR 水平明显高于非痰湿体质组，差异具有统计学意义（P
< 0.05）。痰湿体质、非痰湿体质PCOS 患者外周血CD4+T 淋巴细胞、CD4+/ CD8+明显高于对照组，且痰湿体质PCOS患者CD4+T
淋巴细胞、CD4+/ CD8+明显高于非痰湿体质PCOS 患者，差异有显著性（P＜0.05）。结论：PCOS 患者存在糖脂代谢紊乱，其中痰湿
体质患者较非痰湿体质患者更明显；PCOS患者存在细胞免疫异常，痰湿体质患者较非痰湿体质患者更易出现T淋巴细胞亚群异
常，说明痰湿体质PCOS 的发生与免疫因素关系更密切。 |
| 英文摘要: |
| Objective:To explore the clinical features and distribution of T lymphocyte subsets in the patient with phlegm
dampness of polycystic ovary syndrome:Methods:According to the criteria of diagnosis standard of Rotterdam PCOS and Professor
Wang Qi phlegm constitution, 30 cases of phlegm dampness patients with PCOS and 30 cases of non-phlegm dampness patients with
PCOS and 15 cases of normal control were selected. The level of sex hormone and glucose and lipid metabolism and the distribution of T
lymphocyte subsets and the distribution characteristic of T lymphocyte subsets was detected, and the clinical features of phlegm
dampness patients with PCOS was analyzed.Results:There was no difference in age and body mass index during the three groups. The
level of LH, T, INS 30 min, INS 120 min, CHO, LDL in phlegm dampness and non-phlegm dampness PCOS groups was increased
significantly with statistical significance compared with control group (P<0.05). The level of glucose of OGTT, CHO, LDL, IR in phlegm
dampness PCOS groups was higher than that of non-phlegm dampness PCOS groups. CD4+T lymphocyte, CD4+/CD8+ in both PCOS
groups was increased significantly in compared with control group, more obviously in phlegm dampness PCOS groups than non-phlegm
dampness patients with PCOS(P<0.05).Conclusion:There was glucose and lipid metabolic disorder and cellular immune abnormality in
patients with PCOS, and it was more obvious in the patients with phlegm dampness compared with non phlegm dampness constitution,
suggesting that the pathogenesis of PCOS with phlegmdampness constitution are closely related to the immune factors. |
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