| 夏芳芳 栾天竹△ 梁兆光 姜超 杨建.HMGB1 与冠心病关系的研究进展[J].,2015,15(29):5765-5767 |
| HMGB1 与冠心病关系的研究进展 |
| Research Progress of HMGB1 and Coronary Heart Disease |
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| DOI： |
| 中文关键词: 冠心病 高迁移率族蛋白B1 炎症反应 动脉粥样硬化 |
| 英文关键词: Coronary heart disease HMGB1 Inflammation Atherosclerosis |
| 基金项目:黑龙江省自然科学基金项目（QC2013C100） |
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| 中文摘要: |
| 高迁移率族蛋白B1（high mobility group box1protein，HMGB1）是一种高度保守的核内非组蛋白，可由致病因素引发细胞被
动释放或损伤、凋亡和坏死细胞主动分泌而产生。HMGB1 可以在真核细胞坏死过程中被释放到细胞外。越来越多的研究证明，
HMGB1是一种重要的潜在炎性介质，通过与其特异性受体结合而发挥着重要的炎症细胞因子作用。近年来研究表明，HMGB1通
过参与炎症过程而影响动脉粥样硬化斑块的进展。因此，HMGB1可能是机体冠状动脉炎性疾病的重要靶点。本文对HMGB1及
其作用机制进行综述，为心血管疾病的预防和治疗提供文献依据。 |
| 英文摘要: |
| High mobility group protein B1 ( HMGB1) is a highly conserved nuclear and non histone proteins, cell, which is
caused by the damage or passive release of apoptotic and necrotic cells, as well as the pathogenic factors and active secretions. It can be
released into the extra-cellular space during necrosis of all eukaryotic cells. Besides, more and more evidences have shown that the extracellular
HMGB1 may be a very potential underlying inflammatory mediator. It has been reported that HMGB1 could serve as an important
inflammatory cytokine through binding with its specific receptors. HMGB1 has effect on the in覲ammation, and the progression of
atherosclerotic lesions. Therefore, HMGB1 may be a therapeutic target for the clinical management of coronary artery inflammatory diseases. |
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