| 李志杰 韩世愈 于洋 刘磊.莪术油对Hela细胞迁移及侵袭的初步实验研究[J].,2015,15(31):6009-6011 |
| 莪术油对Hela细胞迁移及侵袭的初步实验研究 |
| Preliminary Study of Zedoary Turmeric Oil on Migration and Invasion ofHela Cells in Vitro |
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| DOI： |
| 中文关键词: 宫颈癌 P15 侵袭 迁移 |
| 英文关键词: Cervical carcinoma P15 Invasion Migration |
| 基金项目:黑龙江省教育厅科学技术研究项目（12511199） |
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| 中文摘要: |
| 目的：探讨莪术油对宫颈癌细胞系Hela 细胞迁移和侵袭的影响。方法：宫颈癌细胞系Hela 细胞培养后分实验组及对照组，
实验组以125 滋g/mL 浓度的莪术油作用48 h，对照组细胞不进行任何处置。细胞划痕实验检测莪术油对Hela细胞迁移的影响；
Transwell小室实验检测莪术油对Hela 细胞侵袭的影响。结果：0 h 处理后实验组、对照组划痕宽度无统计学差异(P>0.05)；48 h后
实验组划痕宽度明显大于对照组的划痕宽度（4.33± 0.58 mvs 2.17± 0.29 m，P<0.05）。实验组48 h 后的穿透细胞数明显少于对
照组（26.2± 1.3 个vs 62.2± 2.3 个，P<0.05）。结论：莪术油可抑制宫颈癌细胞的迁移与侵袭。 |
| 英文摘要: |
| Objective:To investigate the effects of zedoary turmeric oil on migration and invasion of Hela cells.Methods:The cervical
cancer cell line, Hela cells, was divided into experimental group and control group after culture, the cells in the experimental group
were treated with concentration of 125 ug/ml zedoary turmeric oil for 48 h, while the cells in control group were treated without zedoary
turmeric oil. The influence of migration was detected by cell scratch test and the invasion by Transwell chamber assay.Results:There
was no statistical difference between experimental and control groups of cells scratch width on 0 h (P>0.05), the scratch width of the cells
in experimental group was widened r than that in control group after 48 h (4.33± 0.58 mvs 2.17± 0.29 m, P<0.05). The cell numbers of
penetrating in experimental group was significantly less than that in the control group after 48h (26.2± 1.3 vs 62.2± 2.3, P<0.05).Conclusion:Zedoary turmeric oil could inhibit the migration and invasion of cervical cancer cells. |
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