| 李永民 崔滨滨 姜世雄 苑梁 李栗△.解螺旋酶RECQL5 的功能及其在肿瘤中作用的研究进展[J].,2015,15(31):6171-6174 |
| 解螺旋酶RECQL5 的功能及其在肿瘤中作用的研究进展 |
| Research Progress on the Function of RECQL5 Helicase andits Role in the Tumor |
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| DOI： |
| 中文关键词: 解螺旋酶 RECQL5 基因稳定 肿瘤 |
| 英文关键词: Helicase RECQL5 Genetic stability Tumor |
| 基金项目: |
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| 中文摘要: |
| 目前，研究已在小鼠和人类中发现5个RecQ 基因家族成员，分别是Recql1、BLM、WRN、Recql4 和RECQL5。其中，RECQL5
具有抑制姐妹染色体交换、抑制同源重组修复、阻止双链DNA 断裂以及与TOPⅡ 琢的协同作用等功能。最近研究在缺乏
RECQL5 的Apcmin 小鼠小肠和结肠中均发现有肿瘤生长，提示RECQL5 蛋白与肿瘤的发生密切相关。此外，RECQL5 可能是影
响喜树碱(CPT)治疗结直肠癌效果的主要因素，并可能是以伊立替康为基础药物治疗结肠癌效果评估的潜在生物标记物。本文就
解螺旋酶RECQL5 的功能及其在肿瘤中作用的研究进展进行综述。 |
| 英文摘要: |
| The RecQ family have five member, which have been found in the mice and human cell, containing Recql1, BLM,
WRN, Recql4 and RECQL5. As a member of RecQ family, RECQL5 has the fuction of inhibiting the sister chromatid exchange (SCE),
homologous recombination repair (HRR), DNA double-stranded breaks (DSBs) and Synergy with TOPⅡ 琢, etc. Recent studies have
shown that RECQL5 deficiency in Apcmin mice results in a significant increase in the incidence of both the colon and the small intestine
tumor, indicated that there must be relationship between RECQL5 and tumor. In addition, RECQL5 may be a major determinant for CPT
in the treatment of colorectal cancer and a potential biomarker for irinotecan-based treatment for colon cancer. This article review the
research progress on the function of RECQL5 helicase and its role in the tumor. |
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