| 辛克北 张建立 杨娟 卞孝平 魏慧娜.丹参酮IIA 磺酸钠注射液辅助治疗溃疡性结肠炎的临床疗效研究[J].,2015,15(34):6701-6703 |
| 丹参酮IIA 磺酸钠注射液辅助治疗溃疡性结肠炎的临床疗效研究 |
| A Study on the Effect of Tanshinone IIA Sulfonate Injection on the ClinicalEfficacy of Ulcerative Colitis |
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| DOI： |
| 中文关键词: 丹参酮IIA 磺酸钠注射液 溃疡性结肠炎 C 反应蛋白 |
| 英文关键词: Sodiumtanshinone IIA sulfonate injection Ulcerative colitis C reactive protein |
| 基金项目:河南省医学科技攻关计划基金项目(201001004) |
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| 中文摘要: |
| 目的：探究丹参酮IIA 磺酸钠注射液辅助治疗溃疡性结肠炎的临床疗效及其可能的作用机制。方法：选择2013 年1 月～
2014 年10 月我院肝脾胃病科收治的住院患者100 例并将其随机分为实验组与对照组，每组50 例。对照组患者给予美沙拉嗪肠
溶片治疗，而实验组在对照组的基础上给予丹参酮IIA 磺酸钠注射液辅助治疗。治疗后，比较两组患者的临床有效率、结肠镜检查
情况，并检测和比较两组患者治疗前后的C 反应蛋白水平。结果：经治疗后，两组患者溃疡性结肠炎的症状及结肠镜检查结果均
有改善，充血水肿及溃疡处明显减少，脓性分泌物也明显减少或消失，与对照组相比，实验组的总有效率显著升高(P<0.05)，结肠
改善情况更好。两组患者治疗后的CRP水平均较治疗前显著下降，且实验组患者的CRP 水平较对照组更低，差异均具有统计学
意义(P<0.05)。结论：丹参酮IIA 磺酸钠注射液辅助治疗能够有效提高UC的临床疗效，这可能与其降低UC 患者的C 反应蛋白水
平有关。 |
| 英文摘要: |
| Objective:To explore the clinical effects and possible mechanisms of Tanshinone IIA sulfonate injection in the
adjuvant treatment of ulcerative colitis.Methods:100 cases of patients with ulcerative colitis were randomly selected and divided into
two groups. Patients in the control group were treated with Mesalazin, while the experimental group was treated with sodium tanshinone
IIA sulfonate injection on the basis of control group. The clinical efficiency, colonoscopy examination result and C reactive protein level
were compared before and after treatment between two groups.Results:The symptoms and colonoscopy results of two groups were
improved, hyperemia, edema and ulcer were significantly reduced, purulent secretion was significantly reduced or disappeared.
Compared with the control group, the effective rate of experimental group was significantly increased (P<0.05), the CRP levels of both
groups after treatment were significantly lower than those before treatment, which was significantly lower in the experimental group(P<0.
05).Conclusion:Adjuvant treatment with sodium tanshinone IIA sulfonate injection could effectively improve the clinical curative effect
of UC, which might be related to the decrease of CRP level. |
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