| 刘春光 王旭宁 安霞 于小兵 宋金玲 陈晓.艾司洛尔和右旋美托咪啶对减轻患者插管
和喉镜检查的拟交感反应分析[J].,2015,15(34):6746-6749 |
| 艾司洛尔和右旋美托咪啶对减轻患者插管
和喉镜检查的拟交感反应分析 |
| Efficacy of Esmolol and Dexmedetomidine in Attenuating Intubation andLaryngoscopy Sympathomimetic Reaction |
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| DOI： |
| 中文关键词: 右旋美托咪啶 艾司洛尔 拟交感作用 |
| 英文关键词: Dexmedetomidine Esmolol Sympathomimetic response |
| 基金项目:滨州医学院科技计划项目（BY2013KJ086） |
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| 中文摘要: |
| 目的：比较艾司洛尔和右旋美托咪啶减弱神经外科患者插管和喉镜检查的拟交感反应的疗效。方法：选取在我院神经外科拟
接受选择性神经外科手术的90 例患者。患者平均随机分为三组。对照组：静注给予20 mL生理盐水；右旋美托咪啶组：1 ug/kg右
旋美托咪啶使用生理盐水稀释至20 mL静注；艾司洛尔组：1.5 mg/kg 艾司洛尔使用生理盐水稀释至20 mL静注。所有患者均接
受2 min 的麻醉诱导，所有药物均在10 min 内滴注完毕。在给药后、诱导后及气管插管后1、2、3、5、10、15 min 后对患者心率
（HR）、收缩压、舒张压、平均动脉压进行记录，同时记录患者基线值。结果：与对照组相比，右旋美托咪啶组插管后心率和血压未见
显著性差异；艾司洛尔组插管后1、2、3 min 后血压及插管后5 min 的心率显著上升。结论：对减弱神经外科患者插管和喉镜检查
的拟交感作用，右旋美托咪啶比艾司洛尔更为有效。 |
| 英文摘要: |
| Objective:To compare the efficacy of esmolol and dexmedetomidine for elective neurosurgical patients in attenuating
their sympathomimetic response to laryngoscopy and intubation.Methods:90 patients who intended to get elective neurosurgery in our
hospital were selected and randomly allocated to three groups, with 30 cases in each group. The patients in the control group were given
the intravenous injection of 20 mL 0.9% saline, and the patients in dexmedetomidine group were given intravenous injection of 1 ug/kg
dexmedetomidine diluted with 0.9%saline to 20 mL, and the patients in the esmolol group were given intravenous injection of 1.5 mg/kg
esmolol diluted with 0.9%saline to 20 mL. All patients got 2 min induction of anesthesia, and had the drugs injected within 10 min. Then
the heart rate (HR), systolic blood pressure, diastolic blood pressure, and mean arterial pressure were recorded at baseline, right after drug
administration, right after induction and at 1, 2, 3, 5, 10, and 15 min after orotracheal intubation.Results:Compared with the control
group, there was no statistically significant difference in HR and blood pressure after intubation at any time intervals in dexmedetomidine
group. While in esmolol group, there was a statistical significant increase in blood pressure at 1, 2, and 3 min and in HR at 5 min after
intubation.Conclusion:Dexmedetomidine is more effective than esmolol in attenuating the hemodynamic response to laryngoscopy and
intubation for elective neurosurgical patients. |
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