| 吕卫群 周路遥 赵懿清 高秋芳 王生.甲强龙对重型颅脑损伤患者血清IL-1beta和TNF-alpha表达的影响[J].,2015,15(36):7094-7097 |
| 甲强龙对重型颅脑损伤患者血清IL-1beta和TNF-alpha表达的影响 |
| Effect of Methylprednisolone on the Levels of IL-1beta and TNF-alpha in Serum ofPatients with Severe Craniocerebral Injury |
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| DOI： |
| 中文关键词: 甲强龙 重型颅脑损伤 白细胞介素-1beta 肿瘤坏死因子-alpha |
| 英文关键词: Methylprednisolone Severe head injury IL-1beta TNF-alpha |
| 基金项目:江苏省自然科学基金项目(BK2010419) |
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| 中文摘要: |
| 目的：探讨甲强龙对重型颅脑损伤患者血清中白细胞介素-1beta(IL-1beta)及肿瘤坏死因子-alpha(TNF-alpha)的表达影响。方法：收集我
院神经外科以重型颅脑损伤为诊断收治入院的患者68 例，并将其随机分为实验组和对照组。实验组予以甲强龙治疗，对照组则
给予地塞米松治疗，同时两组均予以利尿、降颅压、抗感染、抑酸、营养支持等常规对症支持治疗。分别于治疗前、治疗后第1、3、7
天进行血清IL-1beta和TNF-alpha水平测定，并于治疗3 个月后按GOS预后评分标准进行预后评估。结果：①与治疗前比较，治疗后1
天IL-1beta水平及TNF-alpha水平较高(P＜0.05)，第3、7 天IL-1beta水平及TNF-alpha水平较低(P＜0.05)。与对照组同期比较，实验组第1 天
IL-1beta水平及TNF-alpha水平较高(P＜0.05)，第3、7 天IL-1beta水平及TNF-alpha水平较低(P＜0.05)，②治疗后实验组死亡率明显低于对照
组，差异有统计学意义(P＜0.05)。结论：甲强龙可显著改善重型颅脑损伤患者的预后，这可能与其抑制血清IL-1茁和TNF-琢的表
达有关。 |
| 英文摘要: |
| Objective:To investigate the effect of Methylprednisolone on the IL-1beta and TNF-alpha levels in serum of patients with
severe craniocerebral injury.Methods:68 cases of patients with severe craniocerebral injury from our hospital were selected and randomly
divided into the control group and the experimental group. The experimental group was treated by Methylprednisolone and the control
group was treated by dexamethasone. Both groups were treated by the routine treatment of symptoms, such as diuretic, reducing
intracranial pressure, anti infection, anti acid, nutritional support and so on. The serum levels of IL-1 and TNF-alpha were tested before
treatment and 1, 3, 7 days after treatment. The prognosis was assessed by GOS score after 3 months of treatment.Results:Compared with
before treatment, the IL-1beta level and TNF-alpha level were higher on the 1st day after treatment (P＜0.05), the IL-1beta level and TNF-alpha level
were lower on the 3rd , 7th day after treatment(P＜0.05). Compared with the control group, the IL-1beta level and TNF-alpha level were higher
on the 1st day after treatment (P＜0.05), the IL-1beta level and TNF-alpha level were lower on the 3rd, 7th day after treatment (P＜0.05).
Compared with the control group after treatment, the death rate was significantly lower in the experimental group (P＜0.05).Conclusion: |
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