| 顾峰 李蕾 管燕 赵兰云 丛欣.自然杀伤细胞对妊娠期糖尿病患者并发高脂血症的影响[J].,2015,15(36):7154-7157 |
| 自然杀伤细胞对妊娠期糖尿病患者并发高脂血症的影响 |
| Effect of Natural Killer Cells on Hyperlipidemia of Patients with Gestational Diabetes |
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| DOI： |
| 中文关键词: 自然杀伤细胞 糖尿病 高脂血症 |
| 英文关键词: Natural killer cells Diabetes Hyperlipidemia |
| 基金项目: |
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| 中文摘要: |
| 目的：观察自然杀伤细胞（NK 细胞）对妊娠期糖尿病患者并发高脂血症的影响。方法：选择2013 年2月至2015 年4 月在我
院确诊的妊娠期糖尿病高脂血症患者95 例，作为研究组，同期选择体检健康孕妇100 例，作为对照组，对比两组的血糖、糖化血
红蛋白、身体质量指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、白
细胞介素-2（IL-2）、IL-6、干扰素-r（IFN-r）、NK 细胞及细胞亚型，并采用Person相关性分析NK细胞与血脂的相关性。结果：①研
究组空腹血糖、餐后2 h 血糖、糖化血红蛋白、BMI均明显高于对照组，差异具有统计学意义（P<0.05）；②研究组TC、TG、LDL-C
均明显高于对照组，HDL-C明显低于对照组，差异具有统计学意义（P<0.05）；③研究组IL-2、IFN-r明显低于对照组，差异具有统
计学意义（P<0.05）；IL-6 明显高于对照组，差异具有统计学意义（P<0.05）；④研究组的NK 细胞数量、CD4+/ CD3+、CD4+/ CD8+、
CD56++CD4+/ CD3+均低于对照组的（P<0.05）；CD8+/ CD3+、CD18+/ CD8+、CD19+/ CD3+均高于对照组的（P<0.05）；两组CD28+/
CD8+差异无统计学意义（P＞0.05）。⑤NK 细胞数量与TC、TG、LDL-C水平均呈负相关（r=-0.527、-0.598、-0.485），NK 细胞数量与
HDL-C 水平呈正相关（r=0.528）。结论：NK 细胞在妊娠期糖尿病孕妇中数量减少，活性也降低，可能与参与免疫反应的NK细胞
不同表型细胞含量发生变化，导致血脂调节失衡，引发高血脂症的过程有关。 |
| 英文摘要: |
| Objective:To observe the effect of Natural killer cells on hyperlipidemia of patients with gestational diabetes.Methods:A total of 95 gestational diabetes patients with hyperlipidemia, confirmed in Affiliated Hospital of Qiingdao University during
February 2013 to April 2015, were chosen as research group; 100 healthy pregnant women from a medical physical examination, as
control group at the same time. The levels of blood glucose, glycosylated hemoglobin, body mass index,total cholesterol, triglycerides,
low density lipoprotein cholesterol, high density lipoprotein cholesterol, interleukin-2, IL-6, interferon-gamma, NK cells and the cell
subtype were compared between the two groups. The correlation of NK cells with blood fat was analyzed by the Person correlation
analysis.Results:(1) The levels of fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin, BMI in the research
group were signifi- cantly higher than those in the control group, the differences were statistically significant (P<0.05); (2) The levels of
TC, TG, LDL -C in the research group were significantly higher than those in the control group, the level of HDL-C was significantly
lower than that of the control group, the differences were statistically significant (P<0.05); (3) The levels of IL-2, IFN-r in the research
group were significant- ly lower than those in the control group, with statistically significant differences (P<0.05); the level of IL-6 in the
research group was sig- nificantly higher than that in the control group, with statistically significant differences (P<0.05); (4)The number of
NK cells, CD4+/CD3+, CD4+/CD8+ CD56++CD4+/CD3+ in the research group were lower than those in the control group (P<0.05);
CD8+/CD3+, CD18+/CD8+, CD19+/CD3+ were higher than those in the control group (P<0.05), there was no statistical significance in
CD28+/CD8+ between the two groups (P>0.05). (5) NK cell count was negatively correlated with the levels of TC, TG, LDL-C (r=-0.527,
-0.598, -0.485), positively correlated with HDL-C (r=0.528).Conclusion:The number of NK cells in the pregnant women with
gestational diabetes declines, their activity also reduces, which might be correlated with change of different phenotypes of NK cells
participating in the body's immune response, leading to blood lipid regulation imbalance and the process of hyperlipemia. |
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