| 于少飞 柴少卿 冯万禹 朱华 王文兰.胰岛素样生长因子-1、转化生长因子-beta1 水平变化在过敏性紫癜患儿肾损害的临床意义[J].,2015,15(36):7183-7186 |
| 胰岛素样生长因子-1、转化生长因子-beta1 水平变化在过敏性紫癜患儿肾损害的临床意义 |
| The Clinical Significance of Levels of Insulin-like Growth Factor-1,Transforming Growth Factor-beta 1 in Children with Allergic Purpura KidneyDamage |
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| 中文关键词: 胰岛素样生长因子 转化生长因子-beta1 过敏性紫癜 紫癜性肾炎 |
| 英文关键词: Insulin-like growth factor Transforming growth factor -beta1 Henoch-Schonlein purpura Nephritis |
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| 中文摘要: |
| 目的：探讨胰岛素样生长因子-1（IGF-1）、转化生长因子-beta1（TGF-beta1）水平变化在过敏性紫癜患儿肾损害发病机制中作用。
方法：选取HSP患儿30 例、HSPN患儿30 例和30 例健康儿童为对照组，分别采血，用化学发光法检测各组标本IGF-1 浓度，采用
双抗体一步夹心法酶联免疫吸附试验检测各组TGF-茁1 浓度；同时用全自动生化仪检测各组患儿血清Cys C、BUN、SCr 水平。结
果：血IGF-1、TGF-beta1 的水平HSPN组、HSP组与对照组患儿比较，差异均有统计学意义（P<0.05）。血清Cys C 水平对照组、HSP
组与HSPN 组患儿比较，差异有统计学意义（P<0.05）。采用直线相关分析HSPN 组的血清Cys C 水平与血IGF-1、TGF-beta1 水平
比较，存在正相关（r=0.759、r=0.802,均P<0.05），血IGF-1 与TGF-beta1 也存在正相关（r=0.850，P<0.05）。结论：血IGF-1、TGF-beta1 共同
参与紫癜性肾炎发病，其水平变化与病理损害程度相关。 |
| 英文摘要: |
| Objective:To investigate the roles of insulin-like growth factor -1 (IGF-1) and transforming growth factor -beta1
(TGF-beta1) levels change in the pathogenesis of Henoch-Schonlein purpura (HSP) children with kidney injure.Methods:Selected 30 HSP
children, 30 Henoch-Schoenlein purpura nephritis (HSPN) children and 30 healthy children as control group. Their blood samples were
taken respectively. Chemiluminescence was applied to detect the IGF 1-concentration of the samples, and Double antibody sandwich
enzyme-linked immunosorbent assay was used to detect the concentration of TGF-beta1. Meanwhile, the automatic biochemical analyzer
was applied to detect the serum levels of Cys C, BUN, SCr in each group.Results:(1) The serum levels of IGF-1, TGF-茁1 in HSPN
group and HSP group had statistically significant differences with that of the control group (P <0.05). (2) Compared with the HSPN
group, the serum levels of Cys C in HSP group and control group had statistical differences (P <0.05). (3) The linear correlation analysis
showed that the serumlevel of Cys C had a positive correlation with the blood level of IGF-1 and TGF-beta1 in HSPN group (r=0.759, r=0.
802, P<0.05). The serum level of IGF-1 were also positively correlated with the level of TGF-beta1 (r=0.850, P<0.05).Conclusion:IGF-1
and TGF-beta1 in blood participated in the pathogenesis of Henoch- Schoenlein purpura nephritis, and both were correlated with the degree
of pathological damage. |
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