| 温鑫鑫 严亚波 徐超 王法琪 雷伟.人体颈椎松质骨显微结构和力学性能的区域性差异研究[J].,2016,16(2):212-217 |
| 人体颈椎松质骨显微结构和力学性能的区域性差异研究 |
| Assessment of Regional Variations of Microarchitecture and BiomechanicalParameters in Cervical Vertebral Body |
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| DOI： |
| 中文关键词: 显微CT 松质骨 显微结构 有限元分析 区域性差异 |
| 英文关键词: uCT Cancellous bone Microarchitecture Finite element analysis Regional variation |
| 基金项目:国家自然科学基金项目（81301292） |
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| 中文摘要: |
| 目的：探讨人体脊柱松质骨骨骼显微结构和力学性能的区域性差异，为松质骨三维结构采样部位的选取提供参考。方法：显
微CT扫描6 块颈6椎体标本获得三维图像，依据椎体内解剖位置的不同，将松质骨划分为6 个位置组：外侧、内侧、腹侧、背侧、
头侧和尾侧。利用显微结构参数骨体积分数(Bone volume to tissue volume, BV/TV)、骨表面积和骨体积的比值(Bone surface to
bone volume, BS/BV)、骨小梁数量(Trabecular number, Tb.N)、骨小梁厚度(Trabecular thickness, Tb.Th)、骨小梁分离度(Trabecular
separation, Tb.Sp)和个体化骨小梁分割方法（Individual trabeculae segmentation, ITS）分析6 个位置组内松质骨显微结构，并利用有
限元分析，获得6 个位置组内松质骨的力学性能参数表观弹性模量和表观剪切模量。分别两两对比外侧和内侧，腹侧和背侧，头
侧和尾侧松质骨的显微结构参数（BV/TV、BS/BV、Tb.N、Tb.Th、Tb.Sp 和个体化骨小梁分割得到的参数）和力学性能参数（表观弹
性模量和表观剪切模量）。结果：头侧和尾侧的主要显微结构参数BV/TV、Tb.Th、Tb.N 等和表观弹性模量均存在显著差异（P<0.
05）。腹侧和背侧、内侧和外侧的主要显微结构参数BV/TV、Tb.Th、Tb.N 等无显著差异。外侧和内侧的表观弹性模量在非主方向
即内外方向和腹背放上上存在显著差异（P<0.05），在主方向即头尾上无显著差异。结论：在实验中采集椎体松质骨样本以及临床
上利用高分辨率CT 分析椎体松质骨结构时，感兴趣区域要同时涵盖头侧和尾侧。 |
| 英文摘要: |
| Objective:To assess the regional variation of microarchitecture and biomechanical parameters in vertebral cancellous
bone. And to provide references to how to chose the appropriate region of interest of cancellous bone in the studies of vertebral
cancellous bone.Methods:6 human C5 bodies samples were scanned by micro-CT to get 3 dimensional images. The region of cancellous
bone in the vertebral body were divided into 6 regions: lateral and medial, anterior and posterior, superior and inferior. The measurement
of microarchitectural parameters, finite element analysis, and calculation of biomechanical parameters were performed in all those
regions. All those parameters were compared between lateral and medial, anterior and posterior, superior and inferior regions.Results:The microarchitectural parameters (such as BV/TV, Tb.Th, Tb.N) and apparent elastic modulus between superior and inferior regions
were significantly different(P<0.05). There were no significant differences of microarchitectural parameters(such as BV/TV, Tb.Th, Tb.
N) and apparent elastic modulus between anterior and posterior regions, also between lateral and medial regions. The apparent elastic
modulus between lateral and medial regions were significantly different along the secondary directions (lateral to medial direction, and
anterior to posterior direction) (P<0.05), but along superior and inferior direction were same.Conclusion:When acquiring cancellous
bone specimens from vertebrae or use high-resolution CT to assess vertebral structure, the region of interest should include superior and
inferior regions at the same time. |
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