| 曹学良 付鹏 栾厦 姜廷军 赵长久.CXCR4/CXCL12 在肿瘤中的研究进展[J].,2016,16(3):577-579 |
| CXCR4/CXCL12 在肿瘤中的研究进展 |
| The Research Progress of CXCR4/CXCL12 in Tumors |
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| DOI： |
| 中文关键词: 趋化因子 CXCR4 CXCL12 肿瘤 |
| 英文关键词: Chemokine CXCR4 CXCL12 Tumor |
| 基金项目:黑龙江省青年科学基金项目（QC2011C052） |
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| 中文摘要: |
| 研究表明趋化因子及其受体在胚胎发育、干细胞迁移以及各种免疫反应中发挥重要作用，是许多生理及病理过程中细胞运
动的重要因素。趋化因子受体CXCR4 是一个由352 个氨基酸构成的、7 次跨膜的G 蛋白偶联受体。趋化因子CXCL12 为其特异
性受体。研究发现，CXCR4/CXCL12 在多种肿瘤中都有表达，在肿瘤的生长、血管生成、转移等方面发挥着重要作用。与正常组织
相比，肿瘤组织及转移灶CXCR4 高表达。因此，对CXCR4/CXCL12 轴在肿瘤病生理中的作用机制进行进一步研究，很可能为肿
瘤的治疗及对肿瘤转移的预防提供一个新的思路。我们现在就对其在肿瘤病生理中的作用做一综述。 |
| 英文摘要: |
| Previous studies show that chemokines and their receptors play important roles in embryonic development, stem cell
trafficking and inflammatory reactions. It is the central factor in directing cell movement of many pathologic and physiologic processes.
The chemokines and their receptors play multiple roles in tumor pathogenesis. CXCR4 is a 352 amino acid seven transmembrane
rhodopsin-like G protein-coupled receptor. CXCL12 is the specific ligand for CXCR4. CXCR4/CXCL12 is widely expressed in tumor
cells and has been demonstrated that it promotes tumor growth, enhances tumor angiogenesis, participates in tumor metastasis. Compared
with normal tissue, primary tumor tissue and metastases express high level of CXCR4. So the CXCL12/CXCR4 pathway is an important
target for the development of novel anti-cancer therapies. In this review, we consider the pathological nature and characteristics of the
CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are
discussed. |
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