| 薛孝东 刘定立 李三清 王志坚 倪传斌.多烯磷脂酰胆碱胶囊联合复方益肝灵胶囊治疗抗结核药物致肝损伤患者的临床疗效[J].,2016,16(4):727-729 |
| 多烯磷脂酰胆碱胶囊联合复方益肝灵胶囊治疗抗结核药物致肝损伤患者的临床疗效 |
| Antituberculosis Drug-Induced Liver Injury：Clinical Efficacy of PolyenePhosphatidylcholine Capsule and Compound Yiganling Capsule |
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| DOI： |
| 中文关键词: 多烯磷脂酰胆碱胶囊 复方益肝灵胶囊 抗结核药物 肝损伤 |
| 英文关键词: Polyene phosphatidylcholine capsule Compound Yiganling capsule Antituberculosis drug Liver injury |
| 基金项目: |
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| 中文摘要: |
| 目的：研究多烯磷脂酰胆碱胶囊联合复方益肝灵胶囊治疗抗结核药物致肝损伤患者的临床疗效。方法：选取2014 年4 月到
2015 年4 月我院收治的抗结核药物致肝损伤患者150 例，按照随机数字表法将患者分为研究组和对照组，每组75 例，两组均继
续行抗结核治疗，对照组给予常规保肝药物治疗，研究组给予多烯磷脂酰胆碱胶囊联合复方益肝灵胶囊保肝治疗，比较两组临床
疗效，治疗前后谷丙转氨酶(ALT)、谷草转氨酶(AST)以及r-谷氨酰转移酶（r-GT）。结果：研究组有效率为89.3％显著高于对照组
的73.3％，两组比较差异具有统计学意义（P＜0.05）；两组治疗后AST、ALT 以及r-GT 显著低于治疗前，且治疗后研究组AST、
ALT 以及r-GT 均显著低于对照组，比较差异均具有统计学意义（均P＜0.05）。结论：多烯磷脂酰胆碱胶囊联合复方益肝灵胶囊治
疗抗结核药物致肝损伤具有较好临床疗效，能增强对肝脏的保护作用。 |
| 英文摘要: |
| Objective:To study the clinical efficacy of polyene phosphatidylcholine capsule combined with compound Yiganling
capsule in treatment of antituberculosis drug-induced liver injury.Methods:A total of 150 patients with antituberculosis drug-induced
liver injury, who were admitted to 425 Hospital of People's Liberation Army from April 2014 to April 2015, were selected and randomly
divided into study group (n=75) and control group (n=75). The control group was treated with conventional liver protection drugs, while
the study group, with polyene phosphatidylcholine capsule combined with compound Yiganling capsule. The clinical efficacy and the
levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST) and r-glutamyl transferase(r-GT) in the two groups before and
after treatment were compared.Results:The effective rate(89.3%) of study group was significantly higher than that(73.3%) of the control
group, the difference was statistically significant (P<0.05). The levels of AST, ALT and rGT of two groups after treatment were
significantly lower than before treatment, and the levels of AST, ALT and rGT of study group after treatment were significantly lower
than those of control group, the differences were statistically significant (P<0.05).Conclusion:Polyene phosphatidylcholine capsule plus
compound Yiganling capsule has a better clinical efficacy in the treatment of patients with antituberculosis drug-induced liver injury,
which can enhance the protective effect on the liver. |
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