| 郭梅 肖林 王晓东 吴园 杜丽敏.血清Cys-C 及RBP水平联合检测在早期糖尿病肾病诊断中的应用[J].,2016,16(5):888-890 |
| 血清Cys-C 及RBP水平联合检测在早期糖尿病肾病诊断中的应用 |
| Application of SerumCys-C Combined with RBP Detection to Diagnosis ofEarly Diabetic Nephropathy |
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| DOI： |
| 中文关键词: 胱抑素C 视黄醇结合蛋白 糖尿病肾病 尿素氮 肌酐 |
| 英文关键词: Cystatin C Retinol binding protein Diabetic nephropathy BUN Cr |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨血清胱抑素C（Cys-C）和视黄醇结合蛋白（RBP）水平联合检测在早期糖尿病肾病（DN）诊断中的应用价值。方法：
选择2010 年9 月到2014 年9 月在我院诊疗的150 例DN患者，依照24 h尿清蛋白排泄率（UAER）分为DM 组（n=60 例）、早期
DN组（n=46 例）和临床DN组（n=44例），同期选择82 例健康体检者作为对照组。检测所有患者血清Cys-C、RBP、尿素氮（BUN）
和肌酐（Cr）的浓度，比较各指标的阳性检测率和早期DN组各指标单一、联合检测的灵敏度。结果：早期DN 组和临床DN组血清
Cys-C、RBP 浓度明显高于DM 组和对照组（P<0.05）；临床DN 组血清Cys-C、RBP 浓度明显高于早期DN 组（P<0.05）。早期DN
组血清BUN、Cr 浓度与DM 组和对照组相比，无显著性差异（P>0.05）；临床DN组血清BUN、Cr 浓度明显高于DM 组和对照组
（P<0.05）。早期DN组和临床DN 组血清Cys-C、RBP、BUN及Cr阳性检出率比较无显著性差异（P>0.05）；早期DN 组和临床DN
组血清Cys-C、RBP 阳性检出率明显高于血清BUN、Cr（P<0.05）。早期DN 组血清Cys-C+RBP联合检测灵敏度明显高于血清
Cys-C、RBP、BUN、Cr 的单一检测灵敏度和血清BUN+ Cr 联合检测灵敏度（P<0.05）。结论：血清Cys-C 和RBP 水平联合检测较
BUN、Cr检测早期DN，阳性检出率和灵敏度高，值得在临床上推广应用。 |
| 英文摘要: |
| Objective:To investigate the application value of serum Cystatin C (Cys-C) combined with retinol binding protein
(RBP) detection in diagnosis of early diabetic nephropathy (DN).Methods:A total of 150 patients with early DN, who were treated in
Tianjin 254 Hospital fromSeptember 2010 to September 2014, were selected and divided into diabetes mellitus(DM) group(n=60), early
DN group(n=46) and clinical DN group(n=44) according to the level of UAER within 24 hours; 82 healthy people were chosen as control
group. The concentration of serum Cys-C, RBP, BUN and Cr of all the subjects were detected; The positive detection rates of all the indexes
of the four groups and the sensitivity of single and combined indexes in the early DN group were compared.Results:The concentration
of serum Cys-C and RBP in the early DN group and clinical DN group were significantly higher than that in the DM group and
control group (P<0.05); The concentration of serum Cys-C and RBP in the clinical DN group were significantly higher than that in the
early DN group(P<0.05). The concentration of serumBUN and Cr in the early DN group had no significant difference compared with the
DM group and control group (P>0.05). But the concentration of serum BUN and Cr in the clinical DN group were significantly higher
than that in the DM group and control group (P<0.05). There were no significant differences in the positive detection rates of serum
Cys-C, RBP, BUN and Cr between the early DN group and the clinical DN group (P>0.05). The positive detection rates of serum Cys-C
and RBP were significantly higher than those of serumBUNand Cr in the early DNgroup and clinical DNgroup (P<0.05). The sensitivity
of serum Cys-C combined with RBP detection was significantly higher than that of single serum Cys C, RBP, BUN and Cr detection and
serumBUN combined with Cr detection in the early DN group(P<0.05).Conclusion:The serumCys-C combined with RBP detection has
a higher positive detection rate and sensitivity in the diagnosis of early DN, which is worthy of clinical application. |
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