| 马玉兰 玛依努尔·尼牙孜 朱开春 王芬 张海萌 开丽比努尔·依马木.新疆维吾尔族和汉族妇女宫颈脱落细胞中HPV Ll 壳蛋白的表达比较[J].,2016,16(8):1454-1457 |
| 新疆维吾尔族和汉族妇女宫颈脱落细胞中HPV Ll 壳蛋白的表达比较 |
| Comparison of the Expression of HPV L1 Capsid Protein in the CervicalExfoliated Cell between Uygur and Han Women in Xinjiang |
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| DOI： |
| 中文关键词: 宫颈病变 HPV L1 壳蛋白 维汉妇女 |
| 英文关键词: Cervical lesions HPV L1 capsid protein Uygur and Han women |
| 基金项目:国家自然科学基金项目(81360317) |
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| 中文摘要: |
| 目的：研究HPVL1 壳蛋白在在新疆维吾尔族和汉族妇女宫颈脱落细胞中的表达情况及差异性。方法：收集2012 年9月至
2014 年3月在新疆维吾尔自治区人民医院妇科门诊就诊或行宫颈癌机会性筛查的新疆维吾尔族和汉族妇女病例1160 例，选择
其中HPV 感染阳性或TCT阳性或两项同时阳性的465 例纳入研究队列，通过免疫细胞化学法检测宫颈脱落细胞中HPV L1 蛋
白的表达情况。结果：新疆维吾尔族与汉族妇女HPV L1 壳蛋白的总阳性表达率比较无显著差异(P=0.964)；维吾尔族与汉族妇女
正常或慢性炎症组、CIN1 组、CIN2 组、CIN3 组和SCC 组HPV L1 壳蛋白表达的阳性率比较均无显著差异(P=0.
988，0.957，0.803，0.892，1.000)。新疆维吾尔族妇女和汉族妇女HPV L1 壳蛋白表达的阳性率在C1N1组为最高，高于正常或慢性
炎症组及其它高病变组，且HPV L1 壳蛋白表达的阳性率随宫颈病变恶性程度的增加而降低，呈负相关(相关系数=-0.687 和-0.
379，P<0.001)。结论：新疆维吾尔族与汉族妇女宫颈脱落细胞中HPV L1 壳蛋白的表达不存在民族差异，但其与宫颈病变的恶性
程度呈负相关，可能是宫颈病变的保护性因素之一。 |
| 英文摘要: |
| Objective:To compare the expression of HPV L1 capsid protein in the cervical exfoliated cell between Uygur and Han
women in Xinjiang.Methods:FromSeptember 2012 to March 2014, 1160 cases that consulted a doctor or had an opportunistic screening
of cervical cancer were collected in the department of Xinjiang Uygur Autonomous Region People's Hospital. All the cases were
examined with ThinPrep Cytology Test (TCT) and HPV genotyping, and 465 cases with HPV infection positive or TCT positive or the
both positive were included in the study cohort. All the cases included in the study cohort underwent colposcopy and biopsy, and the
expression of HPV L1 capsid protein was detected by immunocytochemical method.Results:The total positive rate of HPV L1 capsid
protein had no significant difference between Uygur and Han women (P=0.964), and the positive rate in normal or chronic inflammation
group, and the positive rate of CIN1 group, CIN2 group, CIN3 group and SCC group also had no significant difference between Uygur
and Han women(P=0.988, 0.957, 0.803, 0.892, 1.000), the positive rate of HPV L1 capsid protein was highest in CIN1 group, higher than
normal or chronic inflammatory group and other high CIN group; the positive rate of HPV L1 capsid protein decreased with increase of
malignancy (r = -0.687 and -0.379, P<0.001).Conclusion:The expression of HPV L1 capsid protein had no significant difference
between Uygur and Han women in Xinjiang, and HPV Ll capsid protein was negatively correlated with the malignancy of cervical lesions
for Uygur and Han women in Xinjiang. |
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