| 施伟 赵健 宋晓峰 韩平.LincRNA的研究进展[J].,2016,16(9):1762-1765 |
| LincRNA的研究进展 |
| Research Progress of LincRNA |
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| DOI： |
| 中文关键词: LincRNA 保守性 SNP MicroRNA Sponge 疾病 |
| 英文关键词: LincRNA Conservation SNP MicroRNA Sponge Disease |
| 基金项目:国家自然科学基金项目（81270700）；教育部高等学校博士学科点专项科研基金（20133218110016） |
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| 中文摘要: |
| 基因间长链非编码RNA（large intergenic non-coding RNA, lincRNA）是指基因间不编码蛋白质的长度大于200nt的RNA。最
初，lincRNA 被认为是基因组转录的" 噪声"，不具备任何生物学功能。然而，随着第二代测序技术的发展及其所产生的大量数据，
越来越多的lincRNA被识别，引起了人们的重视。至今，已有超过12000 的lincRNAs被收录在人类基因组中。随着研究的深入，
lincRNA的生物机制和潜在的一些功能越来越明朗。本篇综述总结了近年来lincRNA 的研究历程，序列特征，疾病中发挥的作用
以及相关数据库的分析。 |
| 英文摘要: |
| Large intergenic non-coding RNAs (lincRNAs) refer to intergenic non-coding RNAs whose lengths are more than
200nt. Initially lincRNA was considered to be "noise" in the genomic transcription. However, since the development of second-generation
sequencing technology and a large amount of data generated by sequencing technology, the growing number of lincRNAs are identified,
causing people's attention. There are more than 12,000 lincRNAs included in the human genome. With deep research, biological
mechanisms and potential features of lincRNAs become clear. This review summarized the research progress about lincRNAs, sequence
characters, roles played in diseases and relevant databases. |
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