| 王志霞 莫碧文△ 牛坤汀 韦江红 饶立宗.SDF-1/CXCR4 轴在间充质干细胞归巢机制中的研究进展[J].,2016,16(10):1995-1997 |
| SDF-1/CXCR4 轴在间充质干细胞归巢机制中的研究进展 |
| Role of SDF-1/CXCR4 Axis in Mesenchymal Stem Cell HomingMechanisms |
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| DOI： |
| 中文关键词: 间充质干细胞 基质细胞衍生因子-1 趋化因子受体4 归巢 |
| 英文关键词: Mesenchymal stemcells Stromal cell-derived factor 1 C-X-C chemokine receptor 4 Homing |
| 基金项目:国家自然科学基金项目（81260009）；广西自然科学基金重点课题（2012GXNSFDA053020） |
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| 中文摘要: |
| 间充质干细胞(Mesenchymal StemCells, MSCs)是一种具有多向分化潜能的成体干细胞，其具有分泌营养物质和调节炎症反
应的能力，虽然间充质干细胞在组织修复、重塑和免疫调节方面已得到临床运用，但MSCs 趋化和归巢的机制仍不清楚。基质细胞
衍生因子-1（stromal cell-derived factor 1, SDF-1）和其趋化因子受体4（C-X-C chemokine receptor 4，CXCR4）在介导MSCs的分化、
迁移和归巢中起着至关重要的作用，若能深入探讨、明确其在归巢中的作用，期望给间充质干细胞在临床的应用开辟新的应用前
景。 |
| 英文摘要: |
| Mesenchymal stem cells are pluripotent adult stem cells, which have ability to secrete trophic factors and to modulate
inflammatory responses. Although the roles of mesenchymal stem cells in tissue repair, remodeling and immunomodulatory have been
accepted by clinic, however, the mechanism of MSCs Chemotaxis and homing remains unclear. SDF-1/CXCR4 axis plays a vital role in
mediating the differentiation, migration and homing of MSCs. If they could be done an in-depth inquiry, to clarify the mechanisms of
homing, it will contribute to the application of Mesenchymal stemcells in clinic. |
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