| 张倩倩 吕建萍 付玉芹 左丽丽 孙美 张冉 于红霞.血清H-FABP和S-100B 在急性脑梗死患者早期诊断及病情评估中的应用[J].,2016,16(11):2116-2119 |
| 血清H-FABP和S-100B 在急性脑梗死患者早期诊断及病情评估中的应用 |
| Application of Serum H-FABP and S-100B in Early Diagnosis and ConditionAssessment in Patients with Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 心型脂肪酸结合蛋白 S-100B 蛋白 急性脑梗死 早期诊断 病情评估 |
| 英文关键词: Heart type fatty acid binding protein S-100B protein Acute cerebral infarction Early diagnosis Condition assessment |
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| 中文摘要: |
| 目的：探索血清心型脂肪酸结合蛋白（H-FABP）和S-100B 蛋白（S-100B）在急性脑梗死（ACI）患者早期诊断及病情评估中的
应用。方法：选择自2012 年9 月至2015年3 月我院收治的ACI 患者91 例作为观察组，根据Adama 分型法、神经缺损程度和不
同的病发时间进行分组，另外选取健康体检者73 例作为对照组。采集受试者血液，应用酶联免疫吸附法检测血清中H-FABP 和
S-100B 水平，并进行相关性分析。结果：观察组患者发病后第1、3、12 h血清中H-FABP和S-100B水平明显高于对照组（P<0.05）。
观察组患者血清中H-FABP 水平发病第1 h开始升高，在第3 h 达到最高水平，之后开始逐渐下降；S-100B 水平变化趋势同
H-FABP，发病第12 h达到最高水平，之后开始下降。病灶直径越大，患者血清中H-FABP 和S-100B 水平越高，且组间差异均具有
统计学意义（P<0.05）；重度神经缺损患者血清中H-FABP和S-100B 水平明显高于中度和轻度缺损患者，中度神经缺损患者血清
中H-FABP和S-100B水平显著高于轻度缺损患者（P<0.05）；ACI患者血清中H-FABP 和S-100B水平与病灶直径和神经缺损程
度呈正相关（P<0.05）。结论：ACI患者血清中H-FABP 和S-100B 水平可以作为疾病的早期诊断标准之一，同时可以准确评估病情
发展，对于临床检测和确诊具有重要意义，值得在临床上广泛使用。 |
| 英文摘要: |
| Objective:To explore the application of serum heart type fatty acid binding protein (H-FABP) and S-100B protein
(S-100B) in the early diagnosis and condition assessment in patients with acute cerebral infarction (ACI).Methods:A total of 91 patients
with ACI, who were admitted to Cangzhou Central Hospital from September 2012 to March 2015, were chosen as observation group, divided
into subgroups according to the Adama classification method, the degree of nerve defect and different invasion time. Meanwhile,
73 healthy people were selected as control group. The blood of all the participants was collected to detect the levels of serum H-FABP
and S-100B by enzyme-linked immunosorbent method. The correlation of the above indexes with ACI was analyzed.Results:The levels
of serum H-FABP and S-100B in the observation group 1 h, 3 h, 12 h after invasion were significantly higher than those in the control
group(P<0.05). Level of serumH-FABP in the observation group began to increase 1 h after invasion, and kept to the highest level 3 h after
invasion, then it gradually declined; the change trend of S-100B was the same, but the highest level appeared 12 h after invasion, then
it gradually declined. The greater lesions diameter, the higher levels of serum H-FABP and S-100B, the differences were statistically significant
(P<0.05). The levels of serum H-FABP and S-100B in the patients with severe nerve defect were obviously higher than those in
the patients with moderate and mild nerve defect, and the levels of serum H-FABP and S-100B in the patients with moderate nerve defect
were significantly higher than those in the patients with mild nerve defect (P<0.05). The levels of serum H-FABP and S-100B in the patients
with ACI were positively correlated with the lesion diameter and the degree of nerve defect (P<0.05).Conclusion:The levels of
serum H-FABP and S-100B can be used as one of early diagnosis standards for patients with ACI; they can accurately assess the illness
development and have a great significance in the clinical detection and diagnosis,which is worthy of clinical application. |
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