| 王能勇 李海军 郑立 袁颖 肖健.血清Hepcidin 水平在老年缺铁性贫血和慢性病贫血诊断中的临床应用[J].,2016,16(14):2759-2762 |
| 血清Hepcidin 水平在老年缺铁性贫血和慢性病贫血诊断中的临床应用 |
| Application of SerumHepcidin in Diagnosis of Elderly Iron DeficiencyAnemia and Anemia of Chronic Disease |
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| DOI： |
| 中文关键词: 铁调素 缺铁性贫血 慢性病贫血 诊断 |
| 英文关键词: Hepcidin Iron deficiency anemia Anemia of chronic disease Diagnosis |
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| 中文摘要: |
| 目的：探讨血清铁调素（Hepcidin）在老年人群缺铁性贫血（IDA）和慢性病贫血（ACD）中的应用价值。方法：选择老年IDA患
者32 例，老年ACD 患者34 例，健康对照组28 例。检测对比三组血清Hepcidin、血清铁（SI）、血清铁蛋白（SF）、C- 反应蛋白
（CRP）、红细胞数（RBC）、血红蛋白（Hb）、红细胞比容（HCT）、红细胞平均体积（MCV）、白细胞数（WBC）水平。结果：ACD 组中
WBC 明显高于IDA组（P<0.05）。血清Hepcidin 在IDA组、ACD 组及对照组之间具有显著性差异（P<0.05），IDA 组中Hepcidin 含
量比对照组低，而ACD 组中Hepcidin 含量比对照组高（P<0.05）。IDA 组、ACD组中SI 明显低于对照组（P<0.05），而两组间无显
著性差异（P>0.05）。ACD 组中SF、CRP均明显高于IDA 组与对照组（P<0.05）。Hepcidin 诊断IDA组的ROC 曲线下面积（AUC）
值大于诊断ACD组，IDA 组的诊断指数高于ACD组。结论：血清Hepcidin 含量的检测对于鉴别IDA 和ACD 具有重要的意义。 |
| 英文摘要: |
| Objective:To explore the application value of serum hepcidin in elderly iron deficiency anemia (IDA) and anemia of
chronic disease (ACD).Methods:A total of 32 elderly IDA patients, 34 elderly ACD patients, and 28 healthy people ( as control group)
were selected. The levels of serum hepcidin, serum iron (SI), serum ferritin (SF), c-reactive protein (CRP), red blood count (RBC),
hemoglobin(Hb), hematocrit(HCT), mean corpuscular volume(MCV) and white blood count(WBC) in the three groups were detected and
compared.Results:The level of WBC in ACD group was significantly higher than that of IDA group (P<0.05). There was significant
difference in the levels of serum hepcidin in IDA,ACD and control group (P<0.05),and the level of serum hepcidin in IDA group was
lower than that of the control group, while the ACD group was higher than control group (P<0.05). The levels of SI in ACD and IDA
groups were obviously lower than that in control group (P<0.05), but there was no significant difference between ACD group and IDA
group (P>0.05). The levels of SF and CRP in ACD group were obviously higher than those in control group and IDA group(P<0.05).
Hepcidin diagnosis: the area under curve (AUC) value of ROC of IDA group was higher than that of ACD group,and the diagnosis index
of IDA was higher than that of ACD.Conclusion:The detection of serum hepcidin content has important significance for the
identification of IDA and ACD. |
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