| 王道成 毕嘉 黄丽 杨学铭 刘利洪.自身免疫性甲状腺功能紊乱孕妇血清TPOAb 检测的临床价值[J].,2016,16(17):3373-3375 |
| 自身免疫性甲状腺功能紊乱孕妇血清TPOAb 检测的临床价值 |
| Clinical Value of SerumTPOAb Detection in Pregnant Women withAutoimmune Thyroid Disorders |
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| DOI： |
| 中文关键词: 甲状腺功能紊乱 孕妇 甲状腺过氧化物酶抗体 临床价值 |
| 英文关键词: Thyroid disorders Pregnant women Thyroid peroxidase antibody Clinical value |
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| 中文摘要: |
| 目的：探讨血清甲状腺过氧化物酶抗体（TPOAb）对于患有自身免疫性甲状腺功能紊乱的孕妇的临床诊断价值。方法：筛选
2009 年9 月至2013 年1月我院收治的205 例孕妇，其中甲状腺功能紊乱孕妇55 例（紊乱组），非甲状腺功能紊乱孕妇150 例（非
紊乱组）；非紊乱组中，年龄>30 岁的高龄孕妇50 例（高龄组），年龄≤ 30 岁的孕妇100 例（正常组）。采用化学发光法，测定所有孕
妇血清中游离甲状腺三碘原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）和TPOAb 水平。结果：紊乱组患者血清中
TSH、TPOAb 及TPOAb 阳性率水平显著高于非紊乱组，且存在统计学意义（均P<0.05），而两组患者血清中FT3 和FT4水平无统
计学意义（均P>0.05）；高龄组和正常组血清中TSH、FT3、FT4 及TPOAb 水平均无统计学意义（均P>0.05）；与TSH 正常组相比，
TSH 异常组中约有超过半数TPOAb 表现为阳性，有统计学意义（P <0.05）；孕妇体内的TSH水平正常与否，均有出现TPOAb 阳
性的可能，在TSH水平较高（>4.67 mIU/L）中，TPOAb阳性概率更高。结论：TSH 、FT3、FT4 水平正常而TPOAb 呈阳性的孕妇依
然存在自身免疫性甲状腺功能紊乱的可能性，监测TPOAb 的水平对于妊娠期孕妇功能紊乱的诊断与治疗具有重要意义。 |
| 英文摘要: |
| Objective:To study the clinical diagnosis value of serum thyroid peroxidase antibody (TPOAb) in pregnant women
with autoimmune thyroid disorders.Methods:A total of 205 pregnant women, who were treated in Maternal and Children Health Hospital
of Jingyang District fromSeptember 2009 to January 2013, were selected, among which, there were 55 pregnant women with autoimmune
thyroid disorders(disorder group) and 150 pregnant women with non autoimmune thyroid disorders(non disorder group), including
50 pregnant women>30 years old(elder group), and 100 pregnant women≤ 30 years old(normal group). The levels of serumfree three iodine
thyroid original acid(FT3), serum free thyroxine (FT4), serum thyroid stimulating hormone(TSH) and serum TPOAb of all pregnant
women were detected by chemiluminescence method.Results:The positive rates of serum TSH, TPOAb and TPOAb in the disorder
group were significantly higher than those in the non disorder group, the difference was statistically significant (P<0.05), and there were
no significant differences in the levels of serum FT3 and FT4 between the two groups (P>0.05). There were no significant differences in
the levels of serum TSH, FT3, FT4 and TPOAb between the elder group and normal group (P>0.05); Compared with TSH normal group,
there were more than half of positive TPOAb in TSH abnormal group, the difference was statistically significant(P<0.05). Whether or not
the levels of serum TSH in pregnant women were normal, it was possible to appear the positive TPOAb. The probability of positive
TPOAb was higher in higher level of TSH group (>4.67 mIU/L).Conclusion:It is possible for the pregnant women with normal levels of
serum TSH, FT3, and FT4 and positive TPOAb to have autoimmune thyroid disorders, so monitoring the level of serum TPOAb has a
great significance in the diagnosis and treatment of pregnant women with autoimmune thyroid disorders. |
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