| 金德奎 於四军 王文启 吴雨径 刘惠亮.静息心率与慢性心力衰竭患者血清NT-proBNP的相关性分析[J].,2016,16(18):3519-3522 |
| 静息心率与慢性心力衰竭患者血清NT-proBNP的相关性分析 |
| Correlation of Resting Heart Rate on Admission and SerumNT-proBNP inPatients with Chronic Heart Failure |
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| DOI： |
| 中文关键词: 慢性心力衰竭 静息心率 N 末端B 型钠尿肽原 |
| 英文关键词: Chronic heart failure Resting heart rate N-terminal pro-brain natriuretic peptide |
| 基金项目:卫生部医药卫生科技发展项目（W2013GJ09） |
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| 中文摘要: |
| 目的：探讨入院时静息心率与慢性心力衰竭患者血清N末端B型钠尿肽原(NT-proBNP)相关性。方法：选取我院收治的242
例慢性心力衰竭患者为研究对象，按静息心率将患者分为Ⅰ组(心率＜70 次/min)，Ⅱ组(心率: 70%～90 次/min)，Ⅲ组(心率＞90
次/min)；测量患者入院时血清NT-proBNP 水平，按照其中位数分为两组：NT-proBNP＜2087.63 pg/mL 组和NT-proBNP≥
2087.63 pg/mL，比较各组相关指标的差异。用多元线性回归分析静息心率与血清NT-proBNP 的关系。结果：三组在收缩压、心功
能分级、左室射血分数(LVEF)、左室舒张末内径(LVEDD)、空腹血糖(FPG)比较具有统计学差异(P＜0.05)，与Ⅰ组及Ⅱ组比较，Ⅲ
组患者收缩压、LVEDD、FPG，NYHA心功能分级Ⅲ～Ⅳ比例较高、LVEF偏低；三组在血清NT-proBNP 比较亦存在显著的统计学
差异(P＜0.05)，Ⅲ组高于Ⅰ组及Ⅱ组、Ⅱ组高于Ⅰ组；与NT-proBNP＜2087.63 pg/mL组比较，NT-proBNP≥ 2087.63 pg/mL组静息
心率偏快，且患者中＞90(次/min)的比例较高(P＜0.05)。静息心率与与NT-proBNP 呈正相关(r=0.281，P=0.035)；静息心率是影响
NT-proBNP 水平的独立危险因素。结论：静息心率水平与慢性心力衰竭患者血清NT-proBNP水平密切相关。 |
| 英文摘要: |
| Objective:To study the correlation of resting heart rate on admission and serum NT-proBNP in patients with chronic
heart failure.Methods:In our hospital, 242 cases of chronic heart failure patients were selected as research subjects. According to the
resting heart, all patients were divided into groupⅠ (heart rate<70 times/min), groupⅡ (heart rate: 70%~90 times/min), group Ⅲ (heart
rate > 90 times/min). All patients had their NT-proBNP levels detected on admission, and were divided into NT-proBNP < 2087.63
pg/ml group and NT-proBNP ≥ 2087.63 pg/mL group. Related indicators were compared between the groups, and multiple linear
regression analysis was used to analyze the relationship of resting heart rate with the serum NT- proBNP.Results:There were statistically
significant differences in systolic blood pressure, heart function classification, left ventricular ejection fraction (LVEF), left ventricular
end-diastolic diameter (LVEDD), fasting plasma glucose (FPG) between groupⅠ, Ⅱ and Ⅲ (P< 0.05). The systolic blood pressure,
LVEDD, FPG, percentage of NYHA heart function classification Ⅲ~Ⅳ of group Ⅲ were higher than those of group Ⅰand Ⅱ (P<0.05),
and the LVEF was lower. There were also statistically significant differences in NT-proBNP levels between three groups (P<0.05). The
NT-proBNP levels of group Ⅲ were higher than those of groupⅠ and Ⅱ. The resting heart rate of NT-proBNP≥ 2087.63 pg/mL group
was faster than that of NT-proBNP<2087.63 pg/mL group, and the proportion of patients with resting heart rate >90 times/min was higher
in NT-proBNP ≥ 2087.63 pg/mL group (P<0.05). Pearson correlation analysis showed that resting heart rate was positively correlated
with the NT-proBNP level (r=0.281, P =0.035). Multiple linear regression analysis showed that resting heart rate was independent risk
factor of serum NT-proBNP level.Conclusion:Resting heart rate is closely related to the level of serum NT-proBNP in patients with
chronic heart failure. |
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