| 张贵锋 黄泳 曾统军 唐纯志 赖新生.基于fMRI观察正常人脑中枢对针刺得气感反应的初步研究[J].,2016,16(21):4050-4054 |
| 基于fMRI观察正常人脑中枢对针刺得气感反应的初步研究 |
| Functional Magnetic Resonance Imaging for Observing Response of NormalHuman Brain to Needling Sensation |
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| DOI： |
| 中文关键词: 外关穴 针刺得气感 功能性磁共振成像 脑中枢 |
| 英文关键词: Waiguan (SJ5) Needling sensation Functional Magnetic Resonance Imaging /fMRI Central brain |
| 基金项目:国家重点基础研究发展计划（973 项目）（2006CB504505）；国家自然科学基金重大研究计划项目（90709027）；
广东省中医药强省课题（20141306）；肇庆市科技创新计划（2015040304-10） |
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| 中文摘要: |
| 目的：运用功能性磁共振成像技术观察正常人脑中枢对针刺得气感的反应特点，探索针刺得气的物质基础。方法：按照纳入
排除标准收集男、女健康志愿者各35 例，随机分为2 组，针刺组40 人，假针刺组30 人，分别以外关穴针刺与假针刺作为刺激因
素。采用Block方法设计刺激程序，运用功能性磁共振成像技术收集脑中枢反应信号。扫描完毕随即使用针刺感觉量表评价受试
对象的感觉，依据感觉量化结果将图像数据分为针刺得气感组与无感觉对照组，以P≤ 0.0001，uncorrected，K>10 为统计检验显著
性标准，以对照无感觉组为基线，在Matlab 平台上采用SPM2.0 软件包对图像数据进行处理和分析。结果：（1）得气效应：针刺组
29人、假针刺组1 人以酸麻胀重等得气指征为主，VAS 评分4.62± 3.05；针刺组2 人轻微刺痛感，假针刺组21 人无感觉、5 人轻
微刺痛感。（2）脑中枢激活效应：针刺得气激活的脑功能区有双侧额上回（BA6）、额下回（BA47）、缘上回（BA40），左侧额中回
（BA47）、中央前回（BA10）、颞中回（BA21），右侧额中回（BA10）、顶下小叶（BA40）、中央前回（BA6）、颞上回（BA10）、颞中回
（BA39）、颞下回（BA20）。结论：针刺得气感能特异性的激活正常人脑功能区，针刺得气效应与脑中枢密切相关。 |
| 英文摘要: |
| Objective:To observe response of normal human brain center to sensation needling, using functional magnetic resonance
imaging.Methods:According to inclusion and exclusion criteria were collected male and female volunteers, all 35 patients were
randomly divided into 2 groups. Acupuncture group of 40 people, real acupuncture SJ5, 30 people in the control group, sham acupuncture
SJ5. Block programdesigned to stimulate use. Using functional magnetic resonance imaging technology to collect central brain stimulation
signal. The scan is complete then use acupuncture feel Scale Evaluation subjects feeling. According to feel the results of the image
data into quantization needling sensation group and the control group, no feeling. In P≤ 0.0001, uncorrected, K> 10 statistical significance
test standards to the control group without feeling as the baseline. On the Matlab software package platform SPM2.0 image data
processing and analysis.Results:(1) The effects of acupuncture: acupuncture group, 30 people with severe swelling and other needling
sensation tingling indications based, VAS score 4.62± 3.05. The control group of 21 people without feeling, 7 slight tingling. (2) Functional
brain imaging Results:In comparison to the baseline without feeling, SJ5 needling sensation activate brain regions have returned
(BA6) on bilateral frontal, inferior frontal gyrus (BA47), back (BA40) on the edge of the left middle frontal gyrus (BA47), medial frontal
gyrus (BA10), middle temporal gyrus (BA21), on the right middle frontal gyrus (BA10), inferior parietal lobule (BA40), medial frontal
gyrus (BA6), on the back temporal (BA10), middle temporal gyrus (BA39), inferior temporal gyrus (BA20).Conclusion:SJ5 needling
sensation activate brain regions with close ties SJ5 therapeutic effect, the effect of acupuncture mechanisms related to brain center. |
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