| 翟中山 李天昕 陈学宝 陈洪涛 任文杰.甲状腺球蛋白及抗体测定在结节性甲状腺肿与甲状腺癌鉴别诊断中的意义[J].,2016,16(23):4502-4504 |
| 甲状腺球蛋白及抗体测定在结节性甲状腺肿与甲状腺癌鉴别诊断中的意义 |
| Determination of Protein and Antibodies to Thyroglobulin in the DifferentialDiagnosis of Nodular Goiter and Thyroid Carcinoma |
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| DOI： |
| 中文关键词: 甲状腺球蛋白 抗甲状腺球蛋白抗体 甲状腺癌 鉴别诊断 |
| 英文关键词: Thymoglobulin Thymoglobulin antibody Thyroid carcinoma Differential and Diagnosis |
| 基金项目: |
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| 中文摘要: |
| 目的：对结节性甲状腺肿患者和甲状腺癌患者术前的甲状腺球蛋白(TG)、抗甲状腺球蛋白抗体(TG-Ab)水平进行回顾性分
析，并对TG、TG-Ab 水平在结节性甲状腺肿、甲状腺癌诊断中的意义进行研究。方法：分别选取2011 年1 月-2013 年12 月我院
收治的结节性甲状腺肿患者、甲状腺癌患者和正常健康者各60 例作为本研究的观察对象，对三组观察对象TG、TG-Ab 水平进行
比较分析。结果：结节性甲状腺肿组、健康组患者TG阳性率分别为6.67%、8.33%，差异无统计学意义（P>0.05）；两组患者TG-Ab
阳性率则分别为8.33%和11.67%，差异无统计学意义（P>0.05）。而甲状腺癌组患者TG、TG-Ab 阳性率分别为33.33%、40.00%，与
其他两组比较差异具有统计学意义（P<0.05）。在结节性甲状腺肿患者中，其中结节液化型TG 阳性率、TG-Ab 阳性率明显高于非
结节液化型，差异具有统计学意义（P<0.05）。在甲状腺癌患者中，其中颈部淋巴结阳性者TG阳性率、TG-Ab 阳性率明显高于颈部
淋巴结阴性者，差异具有统计学意义（P<0.05）；单结节癌灶与多结节癌灶在TG 阳性率、TG-Ab 阳性率差异无统计学意义（P>0.
05）。结论：临床上采用TG、TG-Ab 阳性率测定的方法对甲状腺肿、甲状腺癌进行鉴别和确诊是比较可靠的，值得推广应用。 |
| 英文摘要: |
| Objective:To study the significance of TG,TG-Ab level in the diagnosis of nodular goiter, thyroid carcinoma by retrospective
analysis that to perform TG, TG-Ab levels on patients with nodular goiter and thyroid cancer patients.Methods:The patients
with nodular goiter, thyroid cancer patients and normal controls patients with each group of 60 cases from January 2011 to December
2013 in our hospital were as the research object of observation, the level of TG and TG-Ab between three groups were compared.Results:The positive rate of healthy group TG patients with nodular goiter group, respectively 6.67%, 8.33%, the difference was not statistically
significant (P>0.05); the positive rate of TG-Ab in the two groups were respectively are 8.33%and 11.67%, the difference was not statistically
significant (P>0.05). And thyroid cancer patients, the positive rate of TG-Ab in TGgroup were 33.33%, 40 %, and other significant
difference between the two groups, with statistical significance (P<0.05). In patients with nodular goiter, TG positive rate, TG-Ab positive
rate of nodular liquefaction type were significantly higher than the no nodules liquefaction type, with statistically significant difference
(P<0.05). In patients with thyroid cancer, TG positive rate, TG-Ab positive rate of cervical lymph node biopsies were significantly higher
than the neck lymph node negatie, with difference (P<0.05); There were no statistically significant differences for TG positive rate,
TG-Ab positive rate between Single nodule cancer and multiple nodules cancer foci (P>0.05).Conclusion:The clinical use of TG, identified
and confirmed on goiter, thyroid cancer is relatively reliable method for determination of the positive rate of TG-Ab, and is worthy of
popularization and application. |
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