| 周云 渠乐 朱小莉 刘芳 王晓峰.阿托伐他汀强化治疗对冠脉介入冠心病患者的保护作用研究[J].,2016,16(27):5317-5320 |
| 阿托伐他汀强化治疗对冠脉介入冠心病患者的保护作用研究 |
| Protective Effect of Atorvastatin Intensive Treatment on Coronary HeartDisease Patients with Percutaneous Coronary Intervention |
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| DOI： |
| 中文关键词: 阿托伐他汀 冠心病 冠脉介入 血小板活化 内皮功能 |
| 英文关键词: Atorvastatin Coronary heart disease Percutaneous coronary intervention Platelet activation Endothelial function |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨阿托伐他汀强化治疗对冠脉介入冠心病患者的保护作用。方法：将86 例择期行经皮冠脉介入(PCI)治疗的冠心病
患者随机分为对照组和观察组，每组各43 例。两组均行常规治疗，对照组在PCI术后服用阿托伐他汀20 mg/d，观察组在PCI 术
前服用阿托伐他汀80 mg，术后服用阿托伐他汀20 mg/d，术后两组均维持服用4 周。比较PCI术前、术后患者血小板活化、内皮功
能及血清肌酸激酶同工酶(CK-MB)、肌钙蛋白I(c TNI)、超敏C 反应蛋白(hs-CRP)水平的变化。结果：术前及术后24 h，两组间血小
板活化指标P- 选择素(CD62P)和血小板膜糖蛋白Ⅱb/Ⅲa(GPⅡb/Ⅲa)水平比较差异无统计学意义(P>0.05)，术后4 周，两组患者
CD62P 和GPⅡb/Ⅲa 水平均较术前及术后24 h显著降低，且观察组降低更显著(P<0.05)；术前及术后24 h，两组间内皮功能指标
内皮素1(ET-1)、一氧化氮(NO)水平比较差异无统计学意义(P>0.05)；术后4 周，两组患者ET-1 水平均较术前及术后24 h显著降
低，NO水平均显著升高，且观察组改变更显著(P<0.05)；术后24 h，两组患者的血清CK-MB、TNI 和hs-CRP 水平均较术前显著升
高(P<0.05)，但观察组升高幅度明显低于对照组(P<0.05)。结论：阿托伐他汀强化治疗可抑制PCI术后血小板活化，改善血管内皮
功能，抑制炎症反应，减少心肌损伤。 |
| 英文摘要: |
| Objective:To investigate the protective effect of atorvastatin intensive treatment on coronary heart disease patients
with percutaneous coronary intervention.Methods:A total of 86 coronary heart disease patients were divided into the observation group
(43 cases) and the control group (43 cases). Both groups were given the conventional therapy, the control group recieved atorvastatin at
the dose of 20 mg/d after PCI, and the observation group recieved extra atorvastatin at the dose of 80 mg before PCI. The serum levels of
platelet activation, endothelial function, CK-MB, TNI and hs-CRP were observed and compared before and after PCI.Results:There was
no significant difference in the CD62P and GPⅡb/Ⅲa before and 24 h after PCI (P>0.05), the levels of CD62P and GPⅡb/Ⅲa were significantly
decreased 4 weeks after PCI than those before and 24 h after PCI, and the observation group decreased more significantly than
in the control group (P<0.05); There was no significant difference in ET-1 and NO before and 24 h after PCI (P>0.05), the level of ET-1
was significantly decreased, the level of NO was significantly increased 4 weeks after PCI than before and 24 h after PCI, and the observation
group changed more significantly than in the control group (P<0.05); the serum levels of CK-MB, TNI and hs-CRP were significantly
increased 24 h after PCI than before PCI, and the control group increased more significantly than in the control group (P<0.05).Conclusion:Atorvastatin intensive treatment could obviously improve the platelet activation, endothelial function, inflammation and myocardial
injury in coronary heart disease patients with percutaneous coronary intervention. |
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