| 蔡泳锋 连大卫 苏锐 任文康 操红缨△ 黄萍.氧化应激与幽门螺杆菌感染相关性胃炎[J].,2016,16(27):5397-5400 |
| 氧化应激与幽门螺杆菌感染相关性胃炎 |
| Oxidative Stress and the Correlation of Helicobactrt Pylori Infection inGastritis |
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| DOI： |
| 中文关键词: 幽门螺杆菌 胃炎 氧化应激 活性氧 活性氮 |
| 英文关键词: Gastritis Oxidative stress Reactive oxygen species Reactive nitrogen species |
| 基金项目:国家自然科学基金项目（81173534）；广东省重大科技专项（20130330） |
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| 中文摘要: |
| 幽门螺杆菌是一种选择性定植于胃上皮细胞的革兰氏阴性菌，是一种广泛传染的病原菌，也是
诱导产生慢性胃炎的主要因素之一。近年来研究表明幽门螺杆菌感染诱导机体产生氧化应激反应，并通过各种逃逸机制避免被
杀灭。幽门螺杆菌能不断刺激中性粒细胞和巨噬细胞表达活性氧和活性氮，导致体内活性氧和活性氮的过度积累，致使细胞的凋
亡和胃粘膜损伤的加剧，这是导致胃炎发生及加重的重要因素。本文对幽门螺杆感染引起氧化应激反应的研究进展作简要综述。 |
| 英文摘要: |
| Helicobacter pylori,one of the main factors to induce chronic gastritis, is a worldwide infectious pathogenic
Gram-negative bacteria which selective colonization in the gastric epithelial cells. In recent years, studies showed that the the infection of H.pylori
can induce the body to produce oxidative stress reaction, and to avoid being killed by various escape mechanism. H.pylori can
constantly simulate neutrophils and macrophages expressing reactive oxygen species (ROS) and reative nitrogen species (RNS) which
lead to excessive accumulation of ROS and RNS. The excessive accumulation of ROS and RNS, causing the increase of apoptosis and
gastric mucosal injury, this is one of the important factors leading to gastritis and aggravating. In this paper, the research progress of oxidative
stress caused by H.pylori is briefly reviewed. |
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