| 罗朝阳 文重远 向朋月 刘璟 吴秋霞.小剂量糖皮质激素联合消炎痛治疗亚急性甲状腺炎的临床效果[J].,2016,16(31):6121-6123 |
| 小剂量糖皮质激素联合消炎痛治疗亚急性甲状腺炎的临床效果 |
| Effect of Low Dose of Glucocorticoid Combined with Indomethacin onSubacute Thyroiditis |
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| DOI： |
| 中文关键词: 亚急性甲状腺炎 糖皮质激素 泼尼松 消炎痛 |
| 英文关键词: Subacute thyroiditis Glucocorticoid Prednisone Indomethacin |
| 基金项目:湖北省自然科学基金项目(2012KFC143) |
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| 中文摘要: |
| 目的：探讨小剂量糖皮质激素联合消炎痛治疗亚急性甲状腺炎(Subacute thyroiditis，ST)的临床效果及安全性。方法：选取我
院内分泌科2012 年6 月-2014 年7 月收治的150 例亚急性甲状腺炎患者，按照随机平均原则即药物治疗的不同将其分为三组，
每组50 例，即泼尼松与消炎痛联合治疗(A 组)、泼尼松单独治疗(B 组)、消炎痛单独治疗(C 组)，对比并分析三组的治疗效果，包括
甲状腺疼痛和肿大平均消失时间，治疗1 周的ESR 平均水平，治疗4 周后的血清TSH、FT3、FT4 水平，并通过随访，观察治疗后8
周患者不良反应的发生率、复发率。结果：(1)A 组患者甲状腺疼痛和甲状腺肿大的消失时间与B 组比较无显著差异(P>0.05)，A、B
组均显著短于C 组(P<0.05)。A 组患者治疗后1 周、4 周的ESR水平与B组对比差异不明显，无统计学意义(P>0.05)；A、B 组患者
治疗后1 周的ESR 水平明显低于C 组(P<0.05)。A、B 组治疗后的血清TSH、FT3、FT4 水平改善程度均优于C 组，差异有统计学意
义(P<0.05)。(2)A 组、C 组的不良反应发生率、复发率均低于B 组，差异具有统计学意义(P<0.05)。结论：采用小剂量糖皮质激素联
合消炎痛治疗亚急性甲状腺炎的临床效果显著，且不良反应和复发情况少。 |
| 英文摘要: |
| Objective:To investigate the clinical effect and safety of small dose of glucocorticoid combined with indomethacin in
the treatment of subacute thyroiditis (ST).Methods:150 cases of patients with ST admitted in the Department of Endocrinology of our
hospital fromJune 2012 to July 2014 were selected and divided into three groups according to the stochastic averaging principle, 50 cases
in each group, who was treated by prednisone and indomethacin (group A), prednisone alone (group B), indomethacin alone (group C),
the curative effect, including thyroid pain and swelling disappeared for 1 weeks on average time, mean levels of ESR, TSH, serum FT3,
FT4 levels at 4 weeks after treatment were compared among three groups and the adverse reactions, recurrence rate were observed
through the follow-up visit.Results:(1) There was no significant difference in the disappearance time of thyroid pain and thyroid enlargement
between groupAand B(P>0.05), which were significantly shorter than that of groupC(P<0.05). There was no significant difference in
ESR level between group A and B at 1 weeks and 4 weeks after treatment (P>0.05), which were significantly lower than that of group C
(P<0.05). Theimprovement of serumTSH, FT3 and FT4 levels in groupA and B were better than those of group C (P<0.05).(2) The incidence
rates of adverse reactions, recurrence rates of group A and C were significantly lower than those of groupB (P<0.05).Conclusion:Small dose of glucocorticoid combined with indomethacin could effectively treat subacute thyroiditis with less adverse reactions and recurrence. |
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