| 汪杰 李宏增 李川 赵待第 郭俊.重症肌无力患者的免疫指标与临床疗效分析[J].,2016,16(31):6162-6164 |
| 重症肌无力患者的免疫指标与临床疗效分析 |
| Analysis of Immune Indexes and Clinical Efficacy in Patients withMyasthenia Gravis |
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| DOI： |
| 中文关键词: 重症肌无力 免疫指标 临床疗效 |
| 英文关键词: Myasthenia Gravis Immune indexes Clincal efficacy |
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| 中文摘要: |
| 目的：探讨并分析重症肌无力（MG）患者的免疫指标和临床治疗效果。方法：选取我院2010 年6 月~2014 年6 月接收的200
例重症肌无力患者，在治疗前和治疗后采用细胞仪检测外周血CD3、CD4 和CD8 及采用比浊法检测IgG、IgA 和IgM，进行分类
比较其变化。结果：全身型重症肌无力患者的IgG、IgA 较眼肌型高（P<0.05），差异具有统计学意义。在治疗前后的免疫指标（CD3、
CD4、CD8、IgG、IgA 及IgM）和临床资料（男/ 女、眼肌型/ 全身型、检测时病程、检测时年龄）的对比中，差异无统计学意义（P>0.
05）。在体液免疫低下组中，用丙种球蛋白治疗的缓解率比未用丙种球蛋白组的缓解率高（P<0.01），差异具有统计学意义。结论：重
症肌无力患者免疫指标IgG、IgA、IgM、CD3、CD4、CD8 虽然不能作为重症肌无力患者的病情和疗效的唯一评价指标，但对指导治
疗具有一定的参考价值，且体液免疫低下者用丙球蛋白的疗效较好。 |
| 英文摘要: |
| Objective:To investigate and analyze the immune index and clinical therapeutic effect of myasthenia gravis (MG) patients.Methods:200 cases of patients with myasthenia gravis were selected, and the level of CD3, CD4 and CD8 was detected by FCM
and the change of IgG, IgA and IgMwas observed by immunoturbidimetry on the classification.Results:The level of IgG and IgA in the
patients with myasthenia gravis were high (P<0.05) in systemic onset, the difference was statistically significant. There was no significant
difference in the immune parameters (CD3, CD4, CD8, IgG, IgA and IgM）and clinical data (male/female, ocular type / systemic onset,
disease course at detecting and age at detecting) before and after treatment(P>0.05). In humoral immunity group, the remission rate in the
patients treated with gamma globulin was higher than that of the patients unused gamma globulin protein group (P<0.01), the difference
was statistically significant. Before and after treatment, there was no significant difference between the immune indexes and clinical data.Conclusion:The immune indexes of IgG, IgA, IgM, CD3, CD4, CD8 have certain reference value for treatment of myasthenia gravis although
they can't be considered as only indexes for the severity and curative effect of this disease, and the patients with low humoral immunity
has great clinical efficacy with γ-globulin. |
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