| 郭鑫 于天源△ 贾文端 马驰 陶艳红.周围神经损伤中P2Y12受体-p38MAPK通路的研究进展[J].,2016,16(31):6186-6191 |
| 周围神经损伤中P2Y12受体-p38MAPK通路的研究进展 |
| Progress on the Research of P2Y12 Receptor-p38MAPK Pathway in Peripheral Nerve Injury |
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| DOI： |
| 中文关键词: 周围神经损伤 小胶质细胞 嘌呤信号通路 P2Y12受体 p38MAPK 磷酸化 |
| 英文关键词: Peripheral nerve injury Microglia Purine signaling pathways P2Y12 receptor Phosphorylation of p38MAPK |
| 基金项目:国家自然科学基金项目（81373759） |
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| 中文摘要: |
| 周围神经损伤是临床中常见的神经损伤之一，神经胶质细胞和信号通路转导在周围神经损伤和再生修复中发挥重要作用。
小胶质细胞的活化与周围神经损伤导致的神经损伤及疼痛密切相关，小胶质细胞是周围神经损伤与修复的关键场所。脊髓背角
的小胶质细胞可被嘌呤信号通路的P2Y12受体活化，进而导致p38MAPK磷酸化，造成相关神经损伤及感觉功能障碍。以脊髓背
角的小胶质细胞为靶点，从P2Y12受体-p38MAPK 通路的角度可揭示周围神经损伤的部分可能机制。探究从嘌呤信号通路与小胶
质细胞活化的新角度，将神经损伤后的P2Y12受体与p38MAPK 的磷酸化表达联系为P2Y12受体-p38MAPK 通路，可为临床治疗
周围神经损伤提供新的思路。本文就周围神经损伤中P2Y12受体-p38MAPK 通路的研究进展作一综述。 |
| 英文摘要: |
| Peripheral nerve injury was one of the common nerve injuries in clinic, and it played an important role in peripheral
nerve injury and regeneration. The activation of microglia was closely related to the nerve injury and pain caused by peripheral nerve
injury, and microglia was an important place for the peripheral nerve injury and repair. The P2Y12 receptor of the purine signaling
pathway can activate the microglia in spinal dorsal horn, which can lead to the phosphorylation of p38MAPK, resulting in the related
nerve injury and sensory dysfunction. Targeting microglia as a target, and revealing the part of the possible mechanisms of peripheral
nerve injury from the perspective of P2Y12 receptor-p38MAPK pathway. To explore a new perspective on the purinergic signaling
pathways and microglia activation, and the P2Y12 receptor and the phosphorylation of p38MAPK was linked to the P2Y12 receptor
-p38MAPK pathway, may provide a new way for the clinical treatment of peripheral nerve injury. P2Y12 receptor-p38MAPK pathway
was reviewed in this article with a purpose of the research progress of the peripheral nerve injury. |
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