| 邢倩 金海燕 李谦 李敬华 王向丽 王斌.SLE 带状疱疹患者外周血CD4+CD28+和CD4+CD25+FoxP3+
调节性T细胞的表达及相关性研究[J].,2017,17(3):481-484 |
| SLE 带状疱疹患者外周血CD4+CD28+和CD4+CD25+FoxP3+
调节性T细胞的表达及相关性研究 |
| The Expression and Correlation of CD4+CD28+T Cells and Treg Cells in thePeripheral Blood of Patients with Systemic Lupus Erythematosus combinedwith Herpes Zoster |
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| DOI： |
| 中文关键词: 系统性红斑狼疮 带状疱疹 T 淋巴细胞亚群 调节性T 细胞 CD28 |
| 英文关键词: Systemic lupus erythematosus Herpes zoster T-lymphocyte subset Regulatory T cells CD28 |
| 基金项目:国家自然科学基金项目（81471958）；青岛市科技局民生计划项目(13-1-3-19-nsh） |
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| 中文摘要: |
| 目的：检测系统性红斑狼疮(systemic lupus erythematosus，SLE)合并带状疱疹患者外周血CD4+CD28+和CD4+CD25+FoxP3+
调节性T 细胞的表达及相关性，探讨其在SLE 合并带状疱疹发病中的临床意义。方法：采用流式细胞术检测30 例SLE 患者、30
例SLE 合并带状疱疹患者及30 例健康对照者外周血中CD4+/CD8+T 淋巴细胞亚群表面CD28 的表达及CD4+CD25+FoxP3+Treg
细胞的表达水平，并分析SLE 合并带状疱疹患者外周血CD4+CD28+和CD4+CD25+FoxP3+调节性T 细胞表达的相关性。结果：
SLE 合并带状疱疹组患者急性期外周血CD4+T 淋巴细胞比率、绝对计数显著降低，CD4+、CD8+T 淋巴细胞表面的CD28 表达下
调，CD4+CD25+FoxP3+Treg细胞水平显著高于SLE 组及健康对照组，SLE 合并带状疱疹组患者外周血CD4+CD25+FoxP3+Treg 水
平与CD4+CD28+水平成负相关(P 均＜0.05)。结论：SLE 合并带状疱疹患者CD4+、CD8+T细胞活化异常，CD4+CD25+FoxP3+Treg 细
胞可能参与抑制了T 细胞的活化。 |
| 英文摘要: |
| Objective:To investigate the expression and correlation of CD28 on CD4+/CD8+T cells and Treg cells in peripheral
blood of systemic lupus erythematosus (SLE) patients with acute herpes zoster and explore the significance of its change in development
of SLE patients with acute herpes zoster.Methods:The expression of CD28 on CD4+/CD8+T cells and frequencies of
CD4+CD25+FoxP3+Treg cells were analyzed by flow cytometry in 30 SLE patients, 30 SLE patients with acute herpes zoster and 30
healthy controls, the correlation of CD4+CD28+T cells and CD4+CD25+FoxP3+Treg cells was analyzed in SLE patients with acute herpes
zoster.Results:It was observed that CD4+, CD4+CD28+, CD8+CD28+T cells were significantly lower and CD4+CD25+FoxP3+Treg cells
were significantly higher and CD4+CD25+FoxP3+Treg cells were correlated negatively with CD4+CD28+T cells in the peripheral blood
from SLE patients with acute herpes zoster than those in SLE Group and in healthy controls (P<0.05).Conclusion:The results demonstrate
that the decline of T cellular immune function may play a key role in the pathogenesis of herpes zoster. CD4+CD25+FoxP3+Treg
cells may be related to the development of SLE with acute herpes zoster. |
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