| 赵一蔚,吴 江,王 领,任培乐,李 静,雷冬玉,代红燕,聂永梅.急性心梗患者血清Fractalkine水平与临床检测指标相关性研究[J].,2017,17(34):6760-6763 |
| 急性心梗患者血清Fractalkine水平与临床检测指标相关性研究 |
| The Correlation of Serum Fractalkine Level with the Clinical Index in Patients with Acute Myocardial Infarction (AMI) |
| 投稿时间：2017-07-23 修订日期：2017-08-19 |
| DOI：10.13241/j.cnki.pmb.2017.34.035 |
| 中文关键词: Fractalkine 动脉粥样硬化 急性心肌梗死(AMI) |
| 英文关键词: Fractalkine Atherosclerosis Acute Myocardial Infarction (AMI) |
| 基金项目:国家自然科学基金项目（11462022）；吉林大学--新疆医科大学联合科学基金项目(01040050505) |
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| 中文摘要: |
| 摘要 目的：分析急性心肌梗死(AMI)患者血清Fractalkine水平，并探讨其与AMI相关临床指标包括白介素-6(IL-6)、C反应蛋白(CRP)、B型利钠肽(BNP)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)等的相关性，以期进一步了解Fractalkine在动脉粥样硬化性疾病中的作用。方法：选取AMI患者与健康对照患者各38例。采用ELISA方法检测研究对象血清中的Fractalkine水平，临床相关检测指标从检验科获取，并进行相关性分析。结果：与对照组相比，急性心梗患者组血清Fractalkine、IL-6、CRP、BNP、CK、CK-MB、TC、LDL-C、LDH表达水平均显著升高，而血清HDL-C水平明显降低，差异均具有统计学意义(P<0.05)。AMI患者血清Fractalkine水平与血清CK、CK-MB、TC、LDL-C水平均存在显著正相关性(r=0.538、r=0.495、r=0.509、r=0.557，P<0.05)。结论：急性心梗患者血清Fractalkine水平异常上调，且与血清CK、CK-MK、TC、LDL-C水平呈显著正相关，Fractalkine可能作为一个AMI的诊断和治疗参考指标。为进一步揭示心血管疾病的发病机制以及有效防治，提供新的思路。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the serum Fractalkine expression level in acute myocardial infarction (AMI) patients and control. To analysis the correlation between serum fractalkine level and indicators associated with AMI (including interleukin 6 (IL-6), C-reactive protein (CRP), Brain natriuretic peptide (BNP), creatine kinase (CK), creatine kinase MB (CK-MB) et.al).In order to further understand the role of Fractalkine in atherosclerotic disease. Methods: Select all the 38 patients with AMI patients and healthy controls. Using ELISA method to test the expression of serum Fractalkine, clinically relevant measurements selected from clinical laboratory. Results: Compared with control group, the AMI group serum Fractalkine, IL-6, CRP, BNP, CK, CK-MB, TC, LDL-C, LDH expression levels were significantly increased, and significantly lower levels of serum HDL-C, the differences were statistically significant (P < 0.05). Among them, the positive correlation are exist between Fractalkine and CK, CK-MB, TC, LDL (r=0.538, r=0.495, r=0.509, r=0.557, P<0.05). Conclusion: Fractalkine significantly expression in patients with AMI. Fractalkine have significant positive correlation with CK, CK-MK, TC, LDL-C. These suggest that Fractalkine also make a testing index to diagnosis AMI. |
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