| 卫 静,吴 巍,杨 璐,孙陈波,黎 璞.2型糖尿病合并急性脑梗死患者血糖波动对体内氧化应激及炎症因子水平的影响及意义[J].,2018,(6):1081-1084 |
| 2型糖尿病合并急性脑梗死患者血糖波动对体内氧化应激及炎症因子水平的影响及意义 |
| Type 2 Diabetes Mellitus Complicated with Acute Cerebral Infarction: Effects of Blood Glucose Fluctuation on Oxidative Stress and Inflammatory Factors |
| 投稿时间：2017-05-30 修订日期：2017-06-23 |
| DOI：10.13241/j.cnki.pmb.2018.06.016 |
| 中文关键词: 2型糖尿病 急性脑梗死 血糖波动 氧化应激 炎症因子 |
| 英文关键词: Type 2 diabetes mellitus Acute cerebral infarction Blood glucose fluctuation Oxidative stress Inflammatory factors |
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| 中文摘要: |
| 摘要 目的：探讨2型糖尿病（T2DM）合并急性脑梗死（ACI）患者血糖波动对体内氧化应激及炎症因子水平的影响及意义。方法：选取2014年3月到2017年1月第四军医大学唐都医院收治的T2DM合并ACI患者100纳入观察组，另选取同期在医院接受治疗的单纯T2DM患者82例作为对照组，比较两组患者的血糖水平标准差（SDBG）、日内平均血糖波动幅度（MAGE） 、日间血糖波动幅度（MODD）、平均餐后血糖波动幅度（MPPGE）、丙二醛（MDA）、尿8-异前列腺素F2α（8-iso-PGF2α）、肿瘤坏死因子α（TNF-α）、超敏C反应蛋白（hs-CRP），并采用Spearman相关分析分析MAGE与MDA、8-iso-PGF2α、hs-CRP、TNF-α的相关性。结果：观察组的SDBG、MAGE、MPPGE、MDA、8-iso-PGF2α、hs-CRP、TNF-α均高于对照组，差异有统计学意义（P<0.05），两组的MODD比较差异无统计学意义（P>0.05）。经Spearman相关分析，MAGE与MDA、8-iso-PGF2α、hs-CRP、TNF-α均呈正相关（r=0.657，0.732，0.724，0.538，P=0.013，0.009，0.010，0.021）。结论：与单纯T2DM患者相比，T2DM合并ACI患者存在较大的血糖波动，同时MAGE与患者体内的氧化应激及炎症因子水平呈正相关，临床上可通过控制血糖波动来降低患者的氧化应激反应程度及炎症因子水平，以改善患者的病情。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the influence and significance of blood glucose fluctuations on oxidative stress and inflammatory factors in patients with type 2 diabetes mellitus (T2DM) complicated with acute cerebral infarction (ACI). Methods: A total of 100 patients with T2DM complicated with ACI, who were treated in Tangdu Hospital of the Fourth Military Medical University from March 2014 to January 2017, were chosen as observation group; and 82 patients with T2DM treated in the hospital in the same period, as control group. The standard deviation of blood glucose (SDBG), daily average blood glucose fluctuation (MAGE), daytime blood glucose fluctuations (MODD), mean amplitude of plasma glucose excursions (MPPGE), malondialdehyde (MDA), urinary 8-iso-prostaglandin F2α (8-iso-PGF2α), tumor necrosis factor-α (TNF-α), high sensitive C reactive protein (hs-CRP) of the two groups were compared.Spearman correlation analysis was used to analyze the correlation between MAGE and MDA, 8-iso-PGF2α, hs-CRP, TNF-α. Results: The SDBG, MAGE, MPPGE, MDA, 8-iso-PGF2α, hs-CRP, TNF-α in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). There was no significant difference in MODD of the two groups (P>0.05). Through the Spearman correlation analysis, MAGE and MDA, 8-iso-PGF2α, hs-CRP, TNF-α were positively related (r=0.657, 0.732, 0.724, 0.538; P=0.013, 0.009, 0.010, 0.021). Conclusion: Compared with simple T2DM patients, there is a greater fluctuation of blood glucose in patients with T2DM complicated with ACI, and MAGE is positively related to the levels of oxidative stress and inflammatory factors of the patients. Clinically, the oxidative stress and the levels of inflammatory factors can be reduced by controlling the fluctuation of blood glucose so as to improve the patient's condition. |
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