| 齐 诠,黄 莉,李子涛,阮建兴,刘风华.年轻POR女性拮抗剂方案与长方案的新鲜移植周期临床妊娠结局的比较分析[J].,2018,(14):2709-2713 |
| 年轻POR女性拮抗剂方案与长方案的新鲜移植周期临床妊娠结局的比较分析 |
| Comparative Analysis of the Clinical Pregnancy Outcome in Fresh Transplantation Cycle Between GnRH-ant Protocol and GnRH-a Long Protocol in Young POR Women |
| 投稿时间：2017-10-08 修订日期：2017-10-30 |
| DOI：10.13241/j.cnki.pmb.2018.14.023 |
| 中文关键词: 年轻女性 卵巢低反应 拮抗剂方案 长方案 妊娠结局 |
| 英文关键词: Young women Poor ovarian response GnRH-ant protocol GnRH-a long protocol Pregnancy outcome |
| 基金项目:广东省自然科学基金项目（2016A030310318） |
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| 中文摘要: |
| 摘要 目的：比较分析拮抗剂方案与长方案对年轻卵巢低反应（POR）女性体外受精（IVF）新鲜移植周期临床妊娠结局的影响，以探讨拮抗剂方案的应用价值。方法：回顾性分析2014年1月至2017年6月在广东省妇幼保健院生殖中心行体外受精-胚胎移植（IVF-ET）治疗的204例妇女213个IVF新鲜移植周期的临床资料。按随机数字表法分为拮抗剂组83例（84治疗周期）与长方案组121例（129治疗周期），比较两组一般资料、实验室资料、促排卵资料及妊娠结局的差异。结果：拮抗剂组的窦卵泡计数（AFC）、抗苗勒氏激素（AMH）水平、促性腺激素（Gn）使用天数、Gn总量、HCG日雌二醇（E2）水平、HCG日内膜厚度、移植日内膜厚度、获卵数、成熟卵子数及正常受精数低于长方案组，基础FSH/LH、Gn启动量高于长方案组（P<0.05），但两组优质胚胎数、移植胚胎数、移植囊胚比例、冷冻胚胎数、胚胎种植率及早期自然流产率比较均无统计学差异（P>0.05）。拮抗剂组和长方案组的临床妊娠率较高，分别为58.14%和63.10%，但是两组临床妊娠率比较无统计学差异（P>0.05）。结论：给予年轻POR患者两种方案均可获得较满意的IVF新鲜移植周期临床妊娠结局，拮抗剂方案获卵数较长方案少，但是其优势在于Gn使用量更少，使用时间更短。 |
| 英文摘要: |
| ABSTRACT Objective: To compare and analyze the clinical pregnancy outcome in fresh transplantation cycle of GnRH-ant proto- col and GnRH-a long protocol in young poor ovarian response (POR) women in vitro fertilization (IVF), in order to discuss the applica- tion value of GnRH-ant protocol. Methods: The clinical data of 213 IVF fresh transplantation cycle in 204 women undergoing in vitro fertilization and embryo transfer (IVF-ET) in the reproductive center of guangdong provincial maternity and child care center from Jan- uary 2014 to June 2017 were analyzed retrospectively. The patients were divided into group GnRH-ant (n=83, 84 treatment cycles) and group GnRH-a (n=121,129 treatment cycles) according to random number table. The differences of general data, laboratory data, ovula- tion induction data and pregnancy outcome between the two groups were compared. Results: The antral follicle count (AFC), anti mulle- rian hormone (AMH) level, days of use gonadotropin (Gn), total Gn dosage, day estradiol (E2) level of HCG, day endometrial thickness of HCG, day endometrial thickness of transplantation, ovum number, mature oocyte number and normal fertilization number in the group GnRH-ant were lower than that in the group GnRH-a, the basal FSH/LH, starting Gn dosage were higher than that in the group GnRH-a (P<0.05). While there were no statistically significant differences in the number of high-quality embryos, the number of embryos trans- ferred, the percentage of blastocysts transplanted, the number of frozen embryos, the rate of embryo implantation and the rate of sponta- neous abortion in the two groups (P>0.05). The clinical pregnancy rate of the group GnRH-ant and group GnRH-a were higher, respec- tively was 58.14% and 63.10%, but there was no significant difference between the two groups in the clinical pregnancy rate (P>0.05). Conclusion: Two kinds of protocols can be given in young POR patients received IVF fresh transfer cycles with satisfactory clinical preg- nancy outcome, the ovum number in the group GnRH-ant were less than that in the group GnRH-a, but Gn uses less and uses less time is its advantage. |
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