| 王海涛,静广平,田 兵,俞 晴,钟克涛,胡腾龙.B7-H1和B7-H4在口腔鳞状细胞癌组织中的表达及临床意义[J].,2018,(19):3623-3627 |
| B7-H1和B7-H4在口腔鳞状细胞癌组织中的表达及临床意义 |
| Expression and Clinical Significance of B7-H1 and B7-H4 in Oral Squamous Cell Carcinoma Tissues |
| 投稿时间：2018-02-28 修订日期：2018-03-23 |
| DOI：10.13241/j.cnki.pmb.2018.19.005 |
| 中文关键词: 口腔鳞状细胞癌 B7-H1 B7-H4 免疫组织化学 |
| 英文关键词: Oral squamous cell carcinoma B7 - H1 B7 - H4 Immunohistochemistry |
| 基金项目:黑龙江省应用技术与开发计划项目（GA14C101-10） |
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| 中文摘要: |
| 摘要 目的：探讨口腔鳞状细胞癌（Oral Squamous Cell Carcinoma，OSCC）中B7-H1和B7-H4的表达及其临床意义，并为OSCC的临床诊断、治疗、判断预后及预防等提供依据。方法：采用免疫组织化学S-P法检测B7-H1及B7-H4在60例OSCC及20例非肿瘤患者正常口腔黏膜组织（NOM）中的表达情况，分析两者与OSCC临床病理特征的相关性。结果：B7-H1在OSCC组织中表达显著高于在NOM组织中表达（29例,48.3%v4例，20%，x2=4.969，P＜0.05）；B7-H4在OSCC组织中表达亦显著高于在NOM组织中表达（31例，51.7%v5例，25%，x2=4.310，P＜0.05）。B7-H1与B7-H4在OSCC组织的表达都与TNM分期、淋巴结转移和肿瘤分化程度显著相关（P＜0.05），而与年龄、性别及肿瘤直径大小等无关。OSCC组织中B7-H1和B7-H4的高表达呈显著性正相关性(x2=5.613 P＜0.05)，60例组织中B7-H1和B7-H4共表达现象有11例（18.3%），NOM中未发现两者共表达现象。结论：B7-H1和B7-H4过表达与OSCC发生、发展及预后有关，可以作为预后指标。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression of B7-H1 and B7-H4 in Oral Squamous Cell Carcinoma (OSCC) and its clinical significance, and provide the basis for clinical diagnosis, treatment, prognosis and prevention of OSCC. Methods: Using immunohisto- chemical S - P method to detect B7 - H1 and B7 - H4 in 60 patients with OSCC and 20 cases of tumor expression innormal oral mucosa tissues(NOM), and the correlation with clinical pathological characteristics of OSCC are analyzed. Results: The expression ofB7-H1 in OSCC was significantly higher than that in the NOM group (29 cases, 48.3% v4, 20%, x2=4.969, P<0.05). The expression of B7-H4 in OSCC was also significantly higher than that in the NOM group (31 cases, 51.7% v5, 25%, x2=4.310, P<0.05). The expression of B7-H1 and B7-H4 in OSCC was significantly correlated with TNM staging, lymph node metastasis and tumor differentiation(P<0.05), regardless of age, sex and tumor diameter. The high expression of B7-H1 and B7-H4 in OSCC tissues showed significant positive correlation (x2=5.613 P<0.05). There were 11 cases (18.3%) in the total expression of B7-H1 and B7-H4 in the 60 cases, and no common expression was found in NOM. Conclusion: B7-H1 and B7-H4 overexpression are associated with the occurrence, development and prognosis of OSCC, which can be used as prognostic indicators. |
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