| 万瑞鑫,贾 肜,刘 辉,秦春妹,赵铁牛.2型糖尿病患者中医证型与糖脂代谢和甲状腺功能的关系[J].,2018,(21):4055-4059 |
| 2型糖尿病患者中医证型与糖脂代谢和甲状腺功能的关系 |
| Relationship between TCM Syndrome Types and Glycolipid Metabolism and Thyroid Function in Patients with type 2 Diabetes Mellitus |
| 投稿时间：2018-04-27 修订日期：2018-05-23 |
| DOI：10.13241/j.cnki.pmb.2018.21.011 |
| 中文关键词: 2型糖尿病 中医证型 血糖 血脂 甲状腺功能 关系 |
| 英文关键词: Type 2 diabetes mellitus TCM syndrome type Blood sugar Blood lipid Thyroid function Relationship |
| 基金项目:天津市自然科学基金项目（13JCZD32402） |
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| 中文摘要: |
| 摘要 目的：探讨2型糖尿病患者中医证型与糖脂代谢和甲状腺功能的关系。方法：选择2016年1月-2017年12月期间武警宁夏总队医院收治的2型糖尿病患者104例，根据中医证型将其分为湿热困脾组23例、阴虚热盛组21例、气阴两虚组20例、阴阳两虚组22例与血瘀脉络组18例。检测并对比不同中医证型2型糖尿病患者糖脂代谢与甲状腺功能指标水平。结果：阴虚热盛组、气阴两虚组、阴阳两虚组与血瘀脉络组甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）水平低于湿热困脾组，高密度脂蛋白胆固醇（HDL-C）水平高于湿热困脾组（P<0.05）；阴阳两虚组TG、TC、LDL-C水平低于阴虚热盛组、气阴两虚组、血瘀脉络组（P<0.05）。湿热困脾组、气阴两虚组、阴阳两虚组与血瘀脉络组空腹血糖（FPG）、餐后2h血糖（2hPPG）、糖化血红蛋白（GHb）水平低于阴虚热盛组（P<0.05）。湿热困脾组、阴虚热盛组、气阴两虚组、血瘀脉络组游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）水平高于阴阳两虚组，促甲状腺激素（TSH）水平低于阴阳两虚组（P<0.05），各组总甲状腺素（TT4）、总三碘甲状腺原氨酸（TT3）水平总体比较差异无统计学意义（P>0.05）。结论：糖脂代谢和甲状腺功能能够在一定程度上反映出2型糖尿病患者的中医证型变化，可作为2型糖尿病患者中医证型与病情变化的有效参考指标。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between TCM syndrome type and glycolipid metabolism and thyroid function in type 2 diabetic patients. Methods: 104 cases of type 2 diabetes mellitus who were treated in Armed Police Corps Hospital of Ningxia from January 2016 to December 2017 were selected. According to TCM syndrome type, they were divided into dampness heat and spleen deficiency group with 23 cases, yin deficiency and heat accumulation group with 21 cases, deficiency of Qi and Yin group with 20 cases, Yin Yang deficiency group with 22 cases and blood stasis syndrome group with 18 cases. The glycolipid metabolism and thyroid function indexes in patients with type 2 diabetes mellitus with different TCM Syndromes were detected and compared. Results: The Triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels in yin deficiency and heat accumulation group, defi- ciency of Qi and Yin group, Yin Yang deficiency group, blood stasis syndrome group were lower than those in the dampness heat and spleen deficiency group, the high density lipoprotein cholesterol (HDL-C) level was higher than that in the dampness heat and spleen de- ficiency group (P<0.05). The levels of TG, TC and LDL-C in Yin Yang deficiency group were lower than those in Yin deficiency and heat accumulation group, deficiency of Qi and Yin group and blood stasis syndrome group (P<0.05). The fasting blood glucose (FPG), postprandial 2H blood glucose (2hPPG) and glycosylated hemoglobin (GHb) level in dampness heat and spleen deficiency group, defi- ciency of Qi and Yin group, Yin Yang deficiency group and blood stasis syndrome group were lower than those in the yin deficiency and heat accumulation group(P<0.05). The free thyroxine (FT4) and free three iodine thyroxine (FT3) level in the dampness heat and spleen deficiency group, yin deficiency and heat accumulation group, deficiency of Qi and Yin group and blood stasis syndrome group were lower than those in Yin Yang deficiency group(P<0.05). There was no significant difference in total thyroxine (TT4) and total three io- dide thyroid (TT3) levels in each group (P>0.05). Conclusion: Glycolipid metabolism and thyroid function can reflect the changes of TCM syndromes in patients with type 2 diabetes. It can be used as an effective reference index for TCM syndromes and changes of type 2 diabetes mellitus. |
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