| 田嘉欣,刘 明,杨海涛,王 冠,李昊怡.右美托咪定用于复合麻醉对腹部手术患者血流动力学及神经认知功能的影响[J].,2018,(21):4110-4113 |
| 右美托咪定用于复合麻醉对腹部手术患者血流动力学及神经认知功能的影响 |
| Effects of Dexmedetomidine on Hemodynamics and Neurocognitive Function in Patients Undergoing Abdominal Surgery with Combined Anesthesia |
| 投稿时间：2018-04-25 修订日期：2018-05-20 |
| DOI：10.13241/j.cnki.pmb.2018.21.024 |
| 中文关键词: 腹部手术 复合麻醉 右美托咪定 血流动力学 神经认知功能 |
| 英文关键词: Abdominal surgery Combined anesthesia Dexmedetomidine Hemodynamics Neurocognitive function |
| 基金项目:辽宁省科技厅自然科学基金项目(201206173) |
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| 中文摘要: |
| 摘要 目的：研究右美托咪定用于复合麻醉对腹部手术患者血流动力学及神经认知功能的影响。方法：选择2016年9月至2017年9月在我院接受复合麻醉条件下腹部手术的患者172例，按照随机分配的原则将其分为试验组(n=90)及对照组(n=82)。观察和比较两组拔管前后平均动脉压、心率、血清瘤坏死因子α(TNF-α)、白介素6(IL-6)、钙粒蛋白β(S100β)水平的变化、拔管时间及躁动的发生情况。术后24小时，通过简易精神状态量表(MMSE)评分评估和比较两组的神经认知功能。结果：试验组拔管前、拔管时及拔管后2小时的平均动脉压、心率、血清TNF-α及IL-6水平均明显低于对照组(P<0.05)，拔管时间及躁动发生率分别为(11.07±2.82)min及5.55%，均显著低于对照组(P<0.05)。术后24小时，试验组的血清S100β蛋白水平为(1.32±0.56)μg/L，明显低于对照组，而MMSE评分为(28.35±2.14)分，显著高于对照组(P<0.05)。结论：右美托咪定应用于施行复合麻醉的腹部手术患者可以更有效的稳定血流动力学，减轻炎症反应，减少躁动，保护患者神经认知功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of dexmedetomidine on the hemodynamics and neurocognitive function of patients undergoing abdominal surgery with combined anesthesia. Methods: 172 cases of patients undergoing abdominal surgery were selected in our hospital from September 2016 to September 2017, the patients were divided into the experimental group (n=90) and the control group (n=82) according to the principle of random distribution. The changes of arterial pressure, heart rate, serum tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and calcium granulin beta (S100 beta) before and after extubation and the occurrence of extubation time and agitation were compared between two groups. The neurocognitive function of the two groups was evaluated and compared by the Mini Mental State Scale (MMSE) score at 24 hours after operation. Results: The mean arterial pressure, heart rate, serum TNF- alpha and IL-6 water of experimental group before extubation, extubation and at 2 hours after extubation were significantly lower than those in the control group (P<0.05). The extubation time and the incidence of restlessness were (11.07±2.82) min and 5.55%, respectively, which were significantly lower than those in the control group (P<0.05). At 24 hours after operation, the serum S100 beta protein level of the test group was (1.32±0.56) μg/L, obviously lower than that of the control group, and the MMSE score was (28.35±2.14) scores, which was significantly higher than that of the control group (P<0.05). Conclusion: Dexmedetomidine should be used in patients with abdomi- nal surgery for complex anesthesia, which could more effectively stabilize the hemodynamics, relieve the inflammation, reduce the agita- tion and protect the neurocognitive function of the patients. |
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