| 曾 赟,王昕炜,尹必俭,沈政洁,毛静瑜.VEGF、P-ACC、LKB1在非小细胞肺癌组织中的表达及意义[J].,2018,(23):4460-4465 |
| VEGF、P-ACC、LKB1在非小细胞肺癌组织中的表达及意义 |
| Expression and Significance of VEGF, P-ACC and LKB1 in Non-small cell Lung Cancer |
| 投稿时间：2018-03-28 修订日期：2018-04-24 |
| DOI：10.13241/j.cnki.pmb.2018.23.014 |
| 中文关键词: 非小细胞肺癌 血管内皮生长因子 磷酸化乙酰辅酶A羟化酶 肝激酶B1 肿瘤微血管密度 |
| 英文关键词: Nonsmall-cell lung cancer Vascular endothelial growth factor Phosphorylated acetyl coenzyme A carboxylase Liver kinase B1 Tumor microvessel density |
| 基金项目:江苏省自然科学基金项目(BK2009167) |
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| 中文摘要: |
| 摘要 目的：探究非小细胞肺癌组织中血管内皮生长因子(VEGF)、磷酸化乙酰辅酶A羟化酶(P-ACC)、肝激酶B1(LKB1)表达及其与肿瘤血管生成的关系。方法：将我院收治的83例非小细胞肺癌(NSCLC)患者作为研究对象，取其NSCLC病理组织样本进行研究，同时取其远离肿瘤的外周正常肺组织作为对照。采用免疫组化法测定其NSCLC病理组织样本和正常组织样本VEGF、P-ACC、LKB1的表达情况，分析比较NSCLC病理组织的VEGF、P-ACC、LKB1表达情况与其病理特征及肿瘤血管生成的关系。结果：NSCLC组织样本的VEGF阳性表达率为72.29%，明显高于癌旁正常组织样本(22.89%)(P<0.05)；同时，其P-ACC、LKB1阳性表达率分别为31.33%、61.45%，明显低于癌旁正常组织样本(分别为75.90%、90.36%)(P<0.05)。NSCLC组织VEGF阳性表达与N分期、临床分期以及肿瘤微血管密度(MVD)有关，P-ACC阳性表达与T分期、临床分期以及MVD有关，LKB1阳性表达与N分期、临床分期、分化程度以及MVD有关(P<0.05)。在样本中，VEGF阳性NSCLC组织的MVD水平明显高于VEGF阴性样本，而P-ACC、LKB1阳性NSCLC组织的MVD水平明显低于阴性样本(P<0.05)。结论：非小细胞肺癌组织中VEGF在呈高表达，P-ACC、LKB1呈现低表达。VEGF、P-ACC、LKB1的表达与NSCLC临床病理特征及肿瘤血管生成均存在密切联系，对于预测NSCLC癌细胞的生长、浸润和转移具有重要意义。 |
| 英文摘要: |
| ABSTRACT Objective: To research the relationship between expression of vascular endothelial growth factor(VEGF), phosphory- lated acetyl coenzyme A carboxylase(P-ACC), liver kinase B1(LKB1) and angiogenesis in non-small cell lung cancer. Methods: 83 pa- tients with nonsmall-cell lung cancer(NSCLC) who treated in our hospital were enrolled in this research. Took the pathological samples of NSCLC for the research, and took the peripheral normal lung tissues away from the tumor as the control. The expressions of VEGF, P-ACC and LKB1 in NSCLC pathological samples and normal tissue samples were measured by immunohistochemistry. Analyzed and compared the expressions of VEGF, P-ACC and LKB1 in NSCLC pathological tissue with their pathological features and tumor angio- genesis. Results: The positive rate of VEGF expression in NSCLC tissue samples was 72.29%, which was significantly higher than that in normal samples of adjacent tissues(22.89%). At the same time, the positive rates of P-ACC and LKB1 were 31.33% and 61.45% respec- tively, which were significantly lower than those of normal tissues beside the cancer(75.90% and 90.36%, respectively), and the differ- ences were statistically significant(P<0.05). The positive expression of VEGF in NSCLC pathological tissue samples was related to N stage, clinical stage and tumor microvessel density(MVD), the positive expression of P-ACC was related to T stage, clinical stage and MVD, the positive expression of LKB1 was related to N stage, clinical stage, differentiation degree and MVD, and the differences were statistically significant(P<0.05). In NSCLC pathological samples, the MVD levels of VEGF positive samples were significantly higher than those of negative samples, and the MVD levels of P-ACC and LKB1 positive samples were significantly lower than those of nega- tive samples, and the differences were statistically significant(P<0.05). Conclusion: In non small cell lung cancer tissues, VEGF showed high expression and P-ACC and LKB1 showed low expression. The expression of VEGF, P-ACC and LKB1 is closely related to the clin- icopathological features and angiogenesis of NSCLC, and have great significance for predicting the growth, invasion and metastasis of NSCLC cancer cells. |
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