| 毛春谱,张晓乐,刘春燕,蔡文婷,张红梅.α-硫辛酸联合前列地尔对糖尿病周围神经病变患者血清炎症因子及神经传导速度的影响[J].,2018,(23):4497-4501 |
| α-硫辛酸联合前列地尔对糖尿病周围神经病变患者血清炎症因子及神经传导速度的影响 |
| Effects of α-Lipoic Acid and Alprostadil on Serum Inflammatory Factors and Nerve Conduction Velocity in Patients with Diabetic Peripheral Neuropathy |
| 投稿时间：2018-03-28 修订日期：2018-04-23 |
| DOI：10.13241/j.cnki.pmb.2018.23.023 |
| 中文关键词: α-硫辛酸 前列地尔 糖尿病周围神经病变 炎症因子 神经传导速度 |
| 英文关键词: α-lipoic acid Alprostadil Diabetic peripheral neuropathy Inflammatory factor Neural conduction velocity |
| 基金项目:江苏省科技计划项目（BK20140324） |
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| 中文摘要: |
| 摘要 目的：探讨α-硫辛酸联合前列地尔对糖尿病周围神经病变患者的疗效及对血清炎症因子、神经传导速度的影响。方法：选取我院2015年6月-2017年6月治疗的130例糖尿病周围神经病变患者，随机分为观察组(n=65)和对照组(n=65)。其中对照组患者采用前列地尔治疗，观察组患者在此基础上联合α-硫辛酸治疗，两组患者均连续治疗2周。对两组患者的临床疗效、治疗前后的神经传导速度、血清炎症因子水平、多伦多临床神经病变评分系统（TCSS）、视觉模拟评分（VAS）、不良反应发生率等指标进行综合评价对比。结果：观察组临床总有效率为93.85%（61/65），高于对照组的78.46%（51/65），（P<0.05）。治疗后，两组患者腓总神经、正中神经的运动神经传导速度（MNCV）、感觉神经传导速度（SNCV）均高于治疗前，观察组高于对照组，组间比较差异显著（P<0.05）。治疗后，两组患者TCSS、VAS评分、肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）、C-反应蛋白（CRP）低于治疗前，观察组低于对照组，组间比较差异明显（P<0.05）。观察组不良反应发生率为13.85%（9/65），对照组为7.69%（5/65），组间相比差异不明显（P>0.05）。结论：α-硫辛酸与前列地尔联合治疗糖尿病周围神经病变，疗效满意，可显著改善患者的神经症状，降低炎症因子水平，且用药安全性好，值得在临床上进一步推广使用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the curative effect of α-lipoic acid and alprostadil on patients with diabetic peripheral neu- ropathy and its effect on serum inflammatory factors and nerve conduction velocity. Methods: 130 patients with diabetic peripheral neu- ropathy who were treated in our hospital from June 2015 to June 2017 were selected, and they were randomly divided into the observa- tion group and the control group according to the random digital table method, 65 cases in each group. The patients in the control group were treated with alprostadil, and the patients in the observation group were treated with α-lipoic acid on the basis of control group, and all patients of two groups were treated for 2 weeks. The clinical efficacy, nerve conduction velocity before and after treatment, serum in- flammatory factor levels, Toronto clinical neuropathy score system(TCSS), visual analogue scale(VAS) and incidence of adverse reac- tions were compared and evaluated between the two groups. Results: The total effective rate of the observation group was 93.85%（61/65）, which was higher than 78.46% of the control group(51/65)(P<0.05). After treatment, motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) of common peroneal nerve and median nerve in two groups were all higher than those be- fore treatment, and the observation group was higher than that in the control group, and the difference between the two groups was statis- tically significant (P<0.05). After treatment, the scores of TCSS, VAS and levels TNF-α (TNF-α), interleukin-6(IL-6) and C-reactive pro- tein(CRP) in the two groups were all lower than those before treatment, and the observation group was lower than that in the control group, the difference between the two groups was statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 13.85% (9/65), and there was no significant difference compared with the control group 7.69% (5/65), the difference between the groups was not obvious (P>0.05). Conclusion: α-lipoic acid combined with alprostadil is effective in the treatment of diabetic periph- eral neuropathy. It can significantly improve the neurological symptoms and reduce the levels of inflammatory factors, and the safety of drug use is good, which is worthy of further promotion in clinical practice. |
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