| 孙延霞,贺 晶,冯 艳,雷 侠,马园园.来曲唑联合妈富隆治疗多囊卵巢综合征患者的疗效探讨[J].,2018,(23):4544-4547 |
| 来曲唑联合妈富隆治疗多囊卵巢综合征患者的疗效探讨 |
| Curative Efficacy of Letrozole Combined with Marvelon in the Treatment of Polycystic Ovary Syndrome |
| 投稿时间：2018-08-02 修订日期：2018-08-27 |
| DOI：10.13241/j.cnki.pmb.2018.23.034 |
| 中文关键词: 多囊卵巢综合征 来曲唑 妈富隆 性激素 |
| 英文关键词: Polycystic ovary syndrome Letrozole Marvelon Sex hormone |
| 基金项目:陕西省自然科学基金项目(20130122) |
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| 中文摘要: |
| 摘要 目的：探讨来曲唑联合妈富隆治疗多囊卵巢综合征患者的临床疗效。方法：选择2015年12月至2017年12月我院接诊的90例多囊卵巢综合征患者，通过随机数表法分为观察组(n=46)和对照组(n=44)。对照组给予妈富隆治疗，观察组联合来曲唑治疗。比较两组治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、血清血管内皮生长因子(VEGF)、内皮抑素(ES)、肝细胞生长因子(HGF)、单核细胞趋化蛋白-1(MCP-1)水平的变化和治疗后的临床疗效，并随访半年，记录排卵率和妊娠率。结果：治疗后，两组血清FSH、LH、T、VEGF、ES、HGF、MCP-1水平均较治疗前明显降低(P＜0.05)，且观察组以上指标均明显低于对照组(P＜0.05)；观察组临床总有效率[91.30% vs. 75.00%]、排卵率[78.26% vs. 36.96%]、妊娠率[59.09% vs. 5.91%]均明显高于对照组(P＜0.05)。结论：来曲唑联合妈富隆治疗多囊卵巢综合征的临床效果显著优于妈富隆单药治疗，其可有效改善患者内分泌，提高妊娠率，可能与降低血清VEGF、ES、HGF、MCP-1的表达相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative efficacy of letrozole combined with marvelon in treatment of polycystic ovary syn- drome. Methods: 90 cases of patients with polycystic ovary syndrome who were treated from December 2015 to December 2017 in our hospital were selected. According to random number table, those patients were divided into the observation group (n=46) and the control group(n=44). The control group was treated with marvelon, while the observation group was combined with letrozole. The changes of serum follicle stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T) and serum ascular endothelial growth factor(VEGF), endostatin(ES), hepatocyte growth factor(HGF) and monocyte chemoattractant protein 1(MCP-1) levels before and after treatment, clini- cal efficacy, ovulation rate and pregnancy rate after six months follow-up were compared between two groups. Results: After treatment, the serum FSH, LH, T, VEGF, ES, HGF and MCP-1 of both groups were significantly lower than those before treatment(P＜0.05), which were significantly lower in the observation group than those of the control group(P＜0.05); the total effective rate[91.30% vs. 75.00%], ovulation rate[78.26% vs. 36.96%] and pregnancy rate[59.09% vs. 5.91%]in the observation group were significantly higher than those of the control group(P＜0.05). Conclusion: Letrozole combined with marvelon was more effective for polycystic ovary syndrome than mar- velon alone, which was helpful to improve the endocrine and increase the pregnancy rate, it's intrinsic mechanism may be related to the decrease of serum VEGF, ES, HGF and MCP-1 levels. |
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