| 张丽武,黄春燕,李 凯,石伟红,李明丽.卡前列素氨丁三醇注射液联合缩宫素对剖宫产出血患者FIB与D-二聚体的影响[J].,2019,19(2):358-361 |
| 卡前列素氨丁三醇注射液联合缩宫素对剖宫产出血患者FIB与D-二聚体的影响 |
| Effect of Carboprost Tromethamine Injection Combined with Oxytocin on FIB and D-dimer of Patients with Postpartum Hemorrhage after Cesarean Section |
| 投稿时间：2018-03-03 修订日期：2018-03-26 |
| DOI：10.13241/j.cnki.pmb.2019.02.035 |
| 中文关键词: 剖宫产 卡前列素氨丁三醇注射液 缩宫素 纤维蛋白原 D-二聚体 |
| 英文关键词: Cesarean section Carboprost tromethamine injection Oxytocin Fibrinogen D-dimer |
| 基金项目:广西壮族自治区卫生厅科研项目(Z2013308) |
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| 中文摘要: |
| 摘要 目的：探讨卡前列素氨丁三醇注射液联合缩宫素用于剖宫产产后出血的预防效果及对纤维蛋白原(FBI)、D-二聚体(D-D)水平的影响。方法：选择2014年1月至2016年10月我院接诊的92例剖宫产产妇，通过随机数表法分为观察组(n=46)和对照组(n=46)。对照组在胎儿娩出后给予缩宫素的宫内注射及静脉滴注，观察组在胎儿娩出后，先给予缩宫素的宫内注射，再在子宫肌壁注射卡前列素氨丁三醇注射液。比较两组产后出血情况、宫缩持续时间、子宫底下降速度、恶露持续时间、FIB、D-D水平及不良反应的发生情况。结果：观察组产后2 h、24 h出血量及产后出血率明显低于对照组(P＜0.05)，宫缩持续时间长于对照组(P＜0.05)，子宫底下降速度快于对照组(P＜0.05)，恶露持续时间明显短于对照组组(P＜0.05)。两组治疗前FIB、D-D水平比较差异无统计学意义(P＞0.05)。治疗后，两组FIB、D-D水平均较治疗前显著降低(P＜0.05)，且观察组FIB、D-D水平均明显低于对照组(P＜0.05)；两组恶心呕吐、面部潮红、胸闷、头痛发生率比较差异无统计学意义(P＞0.05)。结论：在剖宫产产妇中应用卡前列素氨丁三醇注射液联合缩宫素可降低产后出血发生率，且安全性高，可能与有效减少FIB、D-D表达有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the preventive effect of Carboprost Tromethamine Injection combined with oxytocin on the post- partum hemorrhage of cesarean section and its effects on the fibrinogen(FIB) and D-dimer(D-D). Methods: 92 cases of patients with ce- sarean section who were treated from January 2014 to October 2016 in our hospital were selected. According to random number table, those patients were divided into the observation group (n=46) and the control group (n=46). The control group was given oxytocin after delivery of fetus intrauterine injection and intravenous drip, the observation group was firstly given oxytocin intrauterine injection, and then the injection of Carboprost Tromethamine into the uterine wall after delivery of fetus. The postpartum hemorrhage, contraction dura- tion, descending rate of uterine fundus, the duration of lochia, FIB, D-D levels and incidence of adverse reactions were compared be- tween two groups. Results: Compared with the control group, the bleeding volume at 2 h and 24 h after delivery and the postpartum hem- orrhage rate in the observation group were significantly lower(P＜0.05), the contraction duration was longer(P＜0.05), the descending rate of uterine fundus was faster(P＜0.05), the duration of lochia was significantly shorter(P＜0.05). There was no significant difference in the FIB and D-D before treatment between the two groups(P＞0.05). After treatment, the levels of FIB and D-D in both groups were signifi- cantly lower than those before treatment(P＜0.05), and the levels of FIB and D-D in the observation group were significantly lower than those of the control group(P＜0.05); there was no significant difference in the incidence of nausea and vomiting, facial flushing, chest tightness and headache(P＞0.05). Conclusion: Carboprost Tromethamine Injection combined with oxytocin could effectively reduce the incidence of postpartum hemorrhage with high safety, which might be related to the decrease of FIB, D-D levels. |
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