| 苏学旭,仲秀艳,王劲红,孙 刚,刘 静.芪蛭三七汤治疗冠心病稳定型心绞痛气虚血瘀证的疗效及对患者凝血功能和心功能的影响[J].,2019,19(5):951-955 |
| 芪蛭三七汤治疗冠心病稳定型心绞痛气虚血瘀证的疗效及对患者凝血功能和心功能的影响 |
| Effect of Astragalus Membranaceus-leech-pseudo-ginseng Soup in Treatment of Stable Angina Pectoris with Deficiency of Vital energy and Blood Stasis Syndrome |
| 投稿时间：2018-07-20 修订日期：2018-08-15 |
| DOI：10.13241/j.cnki.pmb.2019.05.035 |
| 中文关键词: 稳定型心绞痛 气虚血瘀证 芪蛭三七汤 疗效 凝血功能 心功能 |
| 英文关键词: Stable angina pectoris Deficiency of vital energy and blood stasis syndrome Astragalus membranaceus-leech-pseudo- ginseng soup Curative effect Coagulation function Cardiac function |
| 基金项目:贵州省中医药管理局中医药、民族医药科学技术研究项目（QZYY2013-35） |
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| 中文摘要: |
| 摘要 目的：探讨芪蛭三七汤治疗治疗冠心病稳定型心绞痛气虚血瘀证的疗效及对患者凝血功能和心功能的影响。方法：选取2016年8月到2018年4月在贵阳中医学院第一附属医院接受治疗的稳定型心绞痛患者80例，随机分为对照组和观察组。对照组采用常规西药进行治疗，观察组在对照组的基础上联用芪蛭三七汤进行治疗。治疗1个月后，比较两组患者的心电图有效率和临床有效率，以及两组患者治疗前后的中医症状积分、凝血功能和心功能。结果：观察组的心电图有效率、临床有效率均高于对照组（P<0.05）；治疗后两组患者的中医症候评分低于治疗前，且观察组低于对照组（P<0.05）；与治疗前相比，治疗后两组患者的室间隔后壁厚度(IVSd)、舒张末期左心室内径(LVDd)以及观察组的纤维蛋白原(FIB)明显降低，活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、左室射血分数(LVEF)、早期与晚期峰值流速比值(E/A)明显升高（P<0.05），且治疗后观察组的PT、LVEF、E/A水平高于对照组（P<0.05）。结论：芪蛭三七汤联合常规西药治疗冠心病稳定型心绞痛气虚血瘀证患者具有较好的临床疗效，且可显著改善患者的凝血功能和心功能。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of Astragalus membranaceus-leech-pseudo-ginseng soup in the treatment of stable angina pectoris with deficiency of vital energy and blood stasis syndrome and its effect on blood coagulation function and cardiac function. Methods: A total of 80 patients with stable angina pectoris, who were treated in First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine from August 2016 to April 2018, were selected and were randomly divided into control group and observation group. The control group was treated with conventional western medicine, on the basis of which, the observation group were treated with Astragalus membranaceus-leech-pseudo-ginseng soup. The electrocardiogram efficiency and clinical efficiency were compared between the two groups 1 month after treatment. The symptom integral of traditional Chinese Medicine, blood coagulation function and cardiac function of the two groups were compared before and after treatment. Results: The electrocardiogram efficiency and clinical efficiency in the observation group were higher than those in the control group (P<0.05). After treatment, the symptom integral of traditional Chinese Medicine of the two groups was lower than that before treatment, and the observation group was lower than the control group(P<0.05). After treatment,the interventricular septal thickness at end diastole (IVSd), left ventricular end diastolic dimension (LVDd) of the two groups and fibrinogen(FIB) in the observation group were significantly decreased, and activated partial thromboplastin time(APTT), prothrombin time(PT), left ventricular ejection fraction (LVEF), early and late peak velocity ratio (E/A) were significantly increased (P<0.05). After treatment, the level of PT, LVEF and E/A in the observation group were higher than those in the control group (P<0.05). Conclusion: Astragalus membranaceus-leech-pseudo-ginseng soup combined with conventional western medicine has good clinical effect in the treatment of stable angina pectoris patients with deficiency of vital energy and blood stasis syndrome, and can significantly improve coagulation function and cardiac function of patients. |
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