| 孟 尧,唐重阳,韩志斌,宋维强,汪智华,林志国.MicroRNA与癫痫的研究进展[J].,2019,19(6):1193-1196 |
| MicroRNA与癫痫的研究进展 |
| Advance Studies on MicroRNA and Epilepsy |
| 投稿时间：2018-03-28 修订日期：2018-04-25 |
| DOI：10.13241/j.cnki.pmb.2019.06.043 |
| 中文关键词: 癫痫 MicroRNA 差异性表达 |
| 英文关键词: Epilepsy MicroRNA Differential expression |
| 基金项目:国家自然科学基金重点项目（81571646） |
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| 中文摘要: |
| 摘要：癫痫是大脑神经元高度同步化异常放电所导致的短暂的大脑功能障碍的一种慢性疾病。癫痫的发病原因十分复杂，目前主要治疗方式是药物治疗，但仍然有30%左右的难治性癫痫患者依靠药物治疗未能控制癫痫发作，因此从分子角度研究癫痫的发病机制及治疗是近年来癫痫研究的热点。微小RNA（miRNA）在癫痫患者及癫痫动物模型海马组织中存在差异性表达，通过抑制miRNA的差异表达在一定程度上可以缓解癫痫的症状，这为癫痫的治疗开辟了新的途径和方向。因此随着miRNA与癫痫相关性研究深度的不断加深，有望能够为癫痫的诊断及治疗提供一个全新的思路。 |
| 英文摘要: |
| ABSTRACT: Epilepsy is a chronic disorder of transient brain dysfunction caused by abnormally synchronized discharges of neurons in the brain. The cause of the disease is very complex, although surgical treatment, antiepileptic drugs and other treatment has played a good effect, but there are still about 30% of patients with intractable epilepsy. In recent years, miRNA has been found differentially expressed in epilepsy and epilepsy animal models, and has been found to alleviate the symptoms of epilepsy to some extent by inhibiting the expression of miRNA. MiRNA is expected to open a new way in the treatment of epilepsy, so this article reviewed the research progress of miRNA and epilepsy in recent years. |
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