| 刘殊艳,闫黎娜,赵玉梅,乔 红,郭彦孜.益肺汤联合糖皮质激素治疗小儿难治性支气管肺炎的临床疗效及对患儿免疫功能影响[J].,2019,19(9):1707-1710 |
| 益肺汤联合糖皮质激素治疗小儿难治性支气管肺炎的临床疗效及对患儿免疫功能影响 |
| Efficacy of Yifei Decoction Combined with Glucocorticoid in the Treatment of Refractory Bronchopneum in Children and Its Effect on the Immune Function |
| 投稿时间：2018-12-06 修订日期：2018-12-30 |
| DOI：10.13241/j.cnki.pmb.2019.09.022 |
| 中文关键词: 益肺汤 糖皮质激素 难治性支气管肺炎 免疫功能 |
| 英文关键词: Yifei Decoction Glucocorticoid Refractory bronchopneumonia Immune function |
| 基金项目:内蒙古自治区自然科学基金项目(2016MS(LH)0827) |
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| 中文摘要: |
| 摘要 目的：探究益肺汤联合糖皮质激素治疗小儿难治性支气管肺炎中的临床效果及对患儿免疫功能的影响。方法：选择2015年1月至2017年1月于我院进行治疗的288例难治性支气管肺炎患儿为研究对象，按照随机数字表法将其均分为实验组与对照组，每组各144例患儿。对照组患儿在常规治疗的基础上加用糖皮质激素吸入治疗，实验组患儿在对照组基础上增加益肺汤进行治疗，治疗时间均为7 d，对比两组患儿治疗有效率、临床指标(咳嗽、气喘、肺部湿罗音)改善时间、治疗前后外周血T淋巴细胞亚群指标及血清白介素-8(Interleukine-8，IL-8)、肿瘤坏死因子-α(Tumor necrosis factor-α，TNF-α)水平的变化。结果：(1)治疗后，实验组患儿的治疗有效率为96.53%(139/144)，显著高于对照组患儿(89.58%，P<0.05)；(2)实验组患儿止咳、止喘、肺部湿罗音消失时间均短于对照组(P<0.05)；(3)实验组患儿治疗后CD4+高于对照组，CD8+、血清IL-8、TNF-α水平均显著低于对照组(P<0.05)。结论：益肺汤联合糖皮质激素能够显著改善小儿难治性支气管肺炎临床症状，同时加快其症状转归，增强其免疫功能。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of Yifei Decoction combined with glucocorticoid in the treatment of children with refractory bronchopneumonia and its influence on the immune function. Methods: 288 cases of patients with refractory bronchial pneumonia who were treated in our hospital from January 2015 to January 2017 were selected as the research objects. They were divided into the experimental group and the control group according to the random number table method. There were 144 children in each group. The control group was treated with glucocorticoid inhalation on the basis of routine treatment. The experimental group was treated with glucocorticoid inhalation. On the basis of control group, Yifei Decoction was added for 7 days. The treatment efficiency, improvement time of clinical indicators (cough, asthma, lung moist rale) and T lymphocyte subsets, IL-8 and TNF-α levels in the peripheral blood were compared between the two groups before and after treatment. Results: (1) After treatment, the treatment efficiency of experimental group was 96.53%(139/144), which was significantly higher than that of the control group (89.58%, P<0.05); (2) The disappearance time of cough, asthma and moist rales in the lung of the experimental group was shorter than that of the control group (P<0.05); (3) After treatment, the CD4+ in the experimental group was higher than that in the control group, and the CD8+, serum IL-8 and TNF-α levels were significantly lower than those in the control group(P<0.05). Conclusion: Yifei Decoction combined with glucocorticoid can significantly improve the clinical symptoms of children with refractory bronchopneumonia, accelerate the recovery of symptoms and enhance the immune function. |
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