| 刘 远,叶 云,李明超,张 祚,周吉银.NG2胶质细胞的起源、分布和异质性[J].,2019,19(10):1983-1986 |
| NG2胶质细胞的起源、分布和异质性 |
| The Origin, Distribution and Heterogeneity of NG2-glia |
| 投稿时间：2018-07-06 修订日期：2018-07-30 |
| DOI：10.13241/j.cnki.pmb.2019.10.039 |
| 中文关键词: NG2胶质细胞 起源 分布 异质性 进展 |
| 英文关键词: NG2-glia Origin Distribution Heterogeneity Progress |
| 基金项目:国家自然科学基金项目(81770806，81471040)；重庆市基础与前沿研究计划重点项目(cstc2015jcyjBX0138) |
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| 中文摘要: |
| 摘要：NG2胶质细胞是哺乳动物中枢神经系统中不同于星形胶质细胞、小胶质细胞和少突胶质细胞的一类新型胶质细胞。除分化为少突胶质细胞外，NG2胶质细胞还能分化成星形胶质细胞和神经细胞。NG2胶质细胞能对多种损伤和疾病作出反应，分化为少突胶质细胞，在脱髓鞘后髓鞘修复中起到重要作用。NG2胶质细胞具有异质性，阐明不同发育阶段和区域的差异有助于探寻NG2胶质细胞增殖和分化机制，为预防脱髓鞘和促进髓鞘再生奠定理论基础。本文主要概述NG2胶质细胞的结构、起源和分布，着重讨论NG2胶质细胞不同发育阶段和区域的异质性以及在髓鞘再生疾病中的地位。 |
| 英文摘要: |
| ABSTRACT: In the mammalian central nervous system, NG2-glia represent a new glial cell population that is distinct from astrocytes, microglia and oligodendrocytes. Besides differentiate into oligodendrocytes, NG2-glia can also generate astrocytes and neural cells. NG2-glia can respond to a variety of injuries and diseases, differentiate into oligodendrocytes, and play an important role in myelin repair after demyelination. NG2-glia have heterogeneity, and the elucidation of differences in developmental stages and regions can help to explore the mechanism of proliferation and differentiation of NG2-glia, and lay a theoretical foundation for preventing demyelination and promoting regeneration of myelin sheath.. This article mainly summarizes the structure, origin and distribution of NG2-glia, and focuses on the heterogeneity of NG2-glia in different developmental stages and regions as well as their role in myelin regenerative disease. |
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