| 林小燕,范穗强,杜 钢,孟春想,杜 晶.孟鲁司特钠联合左卡巴斯汀鼻喷剂治疗小儿过敏性鼻炎的疗效评价及对血清ECP、EOS及CRP水平的影响[J].,2019,19(17):3263-3266 |
| 孟鲁司特钠联合左卡巴斯汀鼻喷剂治疗小儿过敏性鼻炎的疗效评价及对血清ECP、EOS及CRP水平的影响 |
| Efficacy Evaluation of Montelukast Sodium Combined with Levorabastine Nasal Spray in the Treatment of Allergic Rhinitis in Children and its Effects on Serum Levels of ECP, EOS and CRP |
| 投稿时间：2019-03-23 修订日期：2019-04-18 |
| DOI：10.13241/j.cnki.pmb.2019.17.012 |
| 中文关键词: 小儿过敏性鼻炎 孟鲁司特钠 左卡巴斯汀鼻喷剂 嗜酸性粒细胞阳离子蛋白 嗜酸性粒细胞 C反应蛋白 |
| 英文关键词: Children allergic rhinitis Montelukast sodium Left carbastine nasal spray Eosinophilic cationic protein Eosinophils C-reactive protein |
| 基金项目:广东省医学科研基金项目(A2014864) |
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| 中文摘要: |
| 摘要 目的：探讨孟鲁司特钠联合左卡巴斯汀鼻喷剂治疗小儿过敏性鼻炎的疗效及对血清嗜酸性粒细胞阳离子蛋白（ECP）、嗜酸性粒细胞（EOS）及C反应蛋白（CRP）水平的影响。方法：选择我院2016年7月~2018年7月收治的151例过敏性鼻炎患儿，按随机数字表法分为69例对照组和82例观察组，对照组采用左卡巴斯汀鼻喷剂治疗，观察组在对照组基础上联合孟鲁司特钠治疗，比较两组临床疗效，治疗前后症状及体征评分，生活质量评分，血清ECP、EOS及CRP、总免疫球蛋白E（TIgE）和特异性免疫球蛋白E（SigE）水平，和不良反应发生情况。结果：观察组总有效率高于对照组，差异有统计学意义（P<0.05）。治疗前，两组症状及体征评分，生活质量评分，血清ECP、EOS及CRP、总免疫球蛋白E（TIgE）和特异性免疫球蛋白E（SigE）水平比较差异无统计学意义（P>0.05）；治疗后，两组以上指标均下降，观察组低于对照组，差异均有统计学意义（均P<0.05）。两组均有胃肠道反应、口干、头痛发生，组间总不良反应发生率比较无统计学差异（P>0.05）。结论：孟鲁司特钠联合左卡巴斯汀鼻喷剂治疗小儿过敏性鼻炎安全有效，能够降低血清ECP、EOS及CRP水平，促进患儿恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy of monclulast sodium combined with levorabastine nasal spray in the treatment of allergic rhinitis in children and the effects on serum levels of eosinophil cationic protein (ECP), eosinophil (EOS) and c-reactive protein (CRP). Methods: 151 cases of children with allergic rhinitis who treated from July 2016 to July 2018 in our hospital, according to random number table method thoese childre were divided into 69 control groups and 82 observation groups, the control group was treated with levocarbastine nasal spray, and the observation group was treated with montelukast sodium on the basis of the control group.then clinical curative effect, the symptoms and signs scores, the quality of life score, serum levels of ECP, EOS and CRP, total immunoglobulin E (TIgE) and specific immunoglobulin E (SIgE) before and after the treatment, and adverse reactions occur in both group were compared. Results: The total effective rate in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Before treatment, the scores of symptoms and signs, quality of life, serum levels of ECP, EOS and CRP, total immunoglobulin E (TIgE) and specific immunoglobulin E (SIgE) showed no significant difference between the two groups (P>0.05). After treatment, the above indicators in both groups were decreased, and the observation group was lower than the control group, and the difference was statistically significant (all P<0.05). Both groups had gastrointestinal reactions, dry mouth, and headache, and there was no statistical difference in the incidence of total adverse reactions between the two groups (P>0.05). Conclusion: Montelukast sodium combined with levorabastine nasal spray is safe and effective in the treatment of allergic rhinitis in children, which can reduce serum levels of ECP, EOS and CRP and promote the recovery of children. |
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