| 曾 旖,赵 希,叶艳艳,杨 军,熊 宇.原发性舍格伦综合征患者血清炎症因子、外周血淋巴细胞亚群分布与病情严重程度的相关性探究[J].,2019,19(17):3275-3279 |
| 原发性舍格伦综合征患者血清炎症因子、外周血淋巴细胞亚群分布与病情严重程度的相关性探究 |
| Correlation of the Serum Levels of Inflammatory Factors and the Distribution of Lymphocyte Subsets in the Peripheral Blood with the Severity of Primary Sjǒgren's Syndrome |
| 投稿时间：2019-02-10 修订日期：2019-03-05 |
| DOI：10.13241/j.cnki.pmb.2019.17.015 |
| 中文关键词: 舍格伦综合征 炎症因子 淋巴细胞亚群 疾病活动度 |
| 英文关键词: Sjǒgren's syndrome Inflammatory factors Lymphocyte subsets Disease activity |
| 基金项目:国家自然科学基金项目(81671022) |
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| 中文摘要: |
| 摘要 目的：探讨原发性舍格伦综合征(pSS)患者血清炎症因子、外周血淋巴细胞亚群分布与病情严重程度的相关性。方法：选取2016年1月至2018年8月我院收治的105例pSS患者为研究对象，根据病程将全部患者分为初发组(n=51)、复发组(n=22)与稳定组(n=32)，并选取同期来我院体检的50例健康成人作为对照组。比较各组患者的血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)与白细胞介素-32(IL-32)水平以及外周血淋巴细胞亚群分布。采用Pearson相关分析探讨pSS患者欧洲抗风湿联盟干燥综合征疾病活动指数(ESSDAI)与其血清炎症因子、外周血淋巴细胞亚群分布的相关性。结果：⑴血清TNF-α、IL-1β水平：初发组、复发组＞稳定组＞对照组；血清IL-32水平：初发组、复发组＞对照组，复发组＞稳定组。⑵外周血CD4+/CD8+比值：初发组、复发组、稳定组＞对照组；外周血Th1/Th2比值：初发组、复发组＞对照组；外周血Th17/Treg比值：初发组、复发组、稳定组＞对照组，且复发组＞稳定组。四组研究对象的外周血T淋巴细胞、B淋巴细胞、NK细胞的百分比比较差异均无统计学意义(P＞0.05)。⑶Pearson相关分析显示pSS患者的ESSDAI评分与血清TNF-α、IL-1β、IL-32水平及外周血Th17/Treg比值均呈显著正相关(r=0.271、0.306、0.251、0.198，P＜0.05)。结论：pSS患者的血清TNF-α、IL-1β与IL-32水平及外周血CD4+/CD8+、Th1/Th2、Th17/Treg比值均明显升高，其中血清TNF-α、IL-1β、IL-32水平、外周血Th17/Treg比值与疾病活动度呈明显正相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation of the serum Levels of Inflammatory Factors and the Distribution of Lymphocyte Subsets in the Peripheral Blood with the Severity of Primary Sjǒgren's Syndrome (pSS). Methods: 105 patients with pSS admitted to our hospital from January 2016 to August 2018 were enrolled for the study anddivided into new-onset group (n=51), relapse group (n=22) and stable group (n=32) according to the course of disease, and 50 healthy adults who came to our hospital for physical examination during the same period were selected as the control group. The serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-32 (IL-32) and the distribution of lymphocyte subsets in peripheral blood were compared among each group. Pearson correlation analysis was performed to investigate the correlation between European League Against Rheumatism Sjǒgren's Syndrome Disease Activity Index (ESSDAI) score of all patients with pSS and serum level of inflammatory factors, the distribution of lymphocyte subsets in peripheral blood. Results: ⑴Serum levels of TNF-α and IL-1β: new-onset group, relapse group > stable group > control group. Serum levels of IL-32: new-onset group, relapse group > control group, and relapse group > stable group. ⑵CD4+/CD8+ ratio in peripheral blood: new-onset group, relapse group, stable group > control group. Th1/Th2 ratio in peripheral blood: new-onset group, relapse group > control group. Th17/Treg ratio in peripheral blood: new-onset group, relapse group, stable group > control group, and relapse group > stable group. There were no significant differences in the percentages of T lymphocyte, B lymphocyte and NK cell in peripheral blood among four groups (P>0.05). (3) Pearson correlation analysis result showed that ESSDAI score of all pSS patients were positively correlated with serum levels of TNF-α, IL-1β, IL-32 and Th17/Treg ratio in peripheral blood (r=0.271, 0.306, 0.251, 0.198, P<0.05). Conclusion: Serum levels of TNF-α, IL-1β, IL-32 and the ratios of CD4+/CD8+, Th1/Th2, Th17/Treg in the peripheral blood of patients with pSS were significantly increased, and serum levels of TNF-α, IL-1β, IL-32 and Th17/Treg in the peripheral blood were positively correlated with disease activity. |
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