| 唐津天,薛 峰,佟 庆,黎旺红,舒 垠,丁 伟,王伯庆.新标志物BDH1用于肝细胞癌术后生存的预测价值分析[J].,2019,19(17):3361-3365 |
| 新标志物BDH1用于肝细胞癌术后生存的预测价值分析 |
| Analysis of the Prognostic Value of BDH1 for the Hepatocellular Carcinoma Patients Underwent Radical Resection |
| 投稿时间：2019-06-06 修订日期：2019-06-30 |
| DOI：10.13241/j.cnki.pmb.2019.17.034 |
| 中文关键词: 3-羟基丁酸脱氢酶1BDH1 肝细胞癌 肝切除术 预后 |
| 英文关键词: 3-Hydroxybutyrate Dehydrogenase 1 (BDH1) Hepatocellular carcinoma Liver resection Prognosis |
| 基金项目:国家自然科学基金项目(NSFC81460360)；新疆维吾尔族自治区自然科学基金项目(2015211C126) |
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| 中文摘要: |
| 摘要 目的：检测肝细胞癌组织中3-羟基丁酸脱氢酶1 (3-Hydroxybutyrate Dehydrogenase 1，BDH1)BDH1的表达情况，探讨其与肝细胞癌患者临床病理特征和术后生存的关系。方法：选取135例肝细胞癌根治性手术患者，整理临床病理及随访资料，调取相应的存档石蜡组织标本切片，采用免疫组化SP方法检测BDH1的表达，对染色结果评分，结合临床病理及随访数据进行统计分析。结果：肝癌细胞中BDH1的阳性表达主要定位于胞浆，阳性表达率为87.4% (118/135)，其中低表达占48.1% (65/135)，高表达占51.9% (70/135)。BDH1的表达与肝癌细胞癌组织分化级别、肿瘤直径、肿瘤数目、微血管侵犯及TNM分期均显著相关(P<0.05)。多因素分析显示BDH1表达、TNM分期、组织分化级别是影响肝癌术后患者预后的独立危险因素(P<0.01)，BDH1高表达者术后总生存率较低表达者显著升高。结论：BDH1可能作为预测肝癌预后的重要参考指标。 |
| 英文摘要: |
| ABSTRACT Objective: To detect the expression of 3-Hydroxybutyrate Dehydrogenase 1 (BDH1) in hepatocellular carcinoma (HCC) and to reveal its relationship with clinicopathological factors and postoperative survival. Methods: 135 patients with hepatocellular carcinoma(HCC) underwent radical operation were selected. Clinical pathological material and follow-up data were collected. Corresponding Paraffin tissue sections were prepared. The expression of BDH1 was detected by immunohistochemistry (SP method). The staining results were scored and analyzed statistically by clinicopathological and follow-up data. Results: The positive signal was localized in the cytoplasm of tumor cells. BDH1 was expressed in 87.4% (118/135) of HCC patients. Low expression was accounted for 48.1% (65/135) and high expression was accounted for 51.9% (70/135). The expression of BDH1 was correlated significantly to tissue differentiation grade, tumor diameter, number of tumors, microvescular invasion and TNM stage (P<0.05). Multivariate analysis demonstrated that the expression of BDH1, TNM stage and tissue differentiation grade were independent risk factors which affecting postoperative survival rate in HCC (P<0.01). Patients in group with high BDH1 expression displayed distinctly higher overall survival rate than that of low BDH1 expression group. Conclusion: BDH1 could be a pivotal prognostic indicator for postoperative survival in HCC patients undergoing surgical resection. |
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