| 董 丽,杨丽霞,郭海霞,陈新卫,刘双江.血清胆红素、YKL-40、HMGB-1对糖尿病合并冠心病患者的临床意义[J].,2019,19(20):3973-3976 |
| 血清胆红素、YKL-40、HMGB-1对糖尿病合并冠心病患者的临床意义 |
| Clinical Significance of Serum Bilirubin, YKL-40 and HMGB-1 in Patients with Diabetes Mellitus Complicated with Coronary Heart Disease |
| 投稿时间：2019-03-25 修订日期：2019-04-19 |
| DOI：10.13241/j.cnki.pmb.2019.20.039 |
| 中文关键词: 胆红素 人类软骨糖蛋白-39 高迁移率族蛋白1 糖尿病 冠心病 |
| 英文关键词: Bilirubin Human cartilage glycoprotein 39 High mobility group protein 1 Diabetes mellitus Coronary heart disease |
| 基金项目:秦皇岛市2011年科学技术研究与发展计划（201101A249） |
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| 中文摘要: |
| 摘要 目的：探讨血清胆红素、人类软骨糖蛋白-39（YKL-40）、高迁移率族蛋白1（HMGB-1）对糖尿病合并冠心病患者的临床意义。方法：选择2017年1月至2018年12月我院接诊的190例2型糖尿病患者，根据是否合并冠心病分为单纯糖尿病组121例和糖尿病合并冠心病组69例，并选择同期在我院接受体检的100例健康者作为对照组。比较三组临床生化指标、血清胆红素、YKL-40、HMGB-1及不同病变支数、不同病变程度糖尿病合并冠心病组血清胆红素、YKL-40、HMGB-1的表达。结果：三组空腹血糖（FBG）、糖化血红蛋白（HbA1c）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、血清胆红素、YKL-40、HMGB-1比较差异均有统计学意义（P＜0.05）；不同病变支数、病变程度糖尿病合并冠心病患者血清胆红素、YKL-40、HMGB-1比较差异均有统计学意义（P＜0.05）；经两两Pearson线性相关性分析结果显示，血清胆红素和Gensini评分呈负相关（r=-0.812，P＜0.01），YKL-40、HMGB-和Gensini评分正相关（r=0.873、0.801，P＜0.01）。结论：在糖尿病合并冠心病患者中，血清胆红素的表达明显降低，YKL-40、HMGB-1明显升高，且随着冠脉病变程度的加重变化更明显，本研究也为后期血清胆红素、YKL-40、HMGB-1在该病的早期诊断、预防、治疗效果评价等方面提供了依据。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical significance of serum bilirubin, Human cartilage glycoprotein 39(YKL-40) and High mobility group protein 1(HMGB-1) in patients with diabetes mellitus complicated with coronary heart disease. Methods: 190 patients of type 2 diabetes mellitus who received therapy from January 2017 to December 2018 in our hospital were selected, according to whether or not coronary heart disease, they were divided into 121 cases in the simple diabetes mellitus group and 69 cases in the diabetes mellitus with coronary heart disease group, and 100 healthy persons who underwent physical examination in our hospital during the same period were selected as the control group. The expression of clinical biochemical indexes, serum bilirubin, YKL-40 and HMGB-1 in three groups, and the expression of serum bilirubin, YKL-40 and HMGB-1 in patients with diabetes mellitus and coronary heart disease group of difference lesions number and lesion degree were compared. Results: There were significant differences in fasting blood glucose (FBG), glycated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), serum bilirubin, YKL-40 and HMGB-1 among the three groups(P＜0.05); there were significant differences in serum bilirubin, YKL-40 and HMGB-1 in patients with diabetes mellitus and coronary heart disease group of difference lesions number and lesion degree(P＜0.05); the results of Pearson linear correlation analysis showed that serum bilirubin was negatively correlated with Gensini score (r=-0.812, P＜0.01), while YKL-40, HMGB-1 were positive correlated with Gensini score(r=0.873, 0.801, P＜0.01). Conclusion: In patients with diabetes mellitus and coronary heart disease, the expression of serum bilirubin was significantly decreased, the YKL-40 and HMGB-1 were significantly increased, and the change was more obvious with the aggravation of coronary artery disease, this study also provides a basis for the early diagnosis, prevention and therapeutic evaluation of serum bilirubin, YKL-40 and HMGB-1. |
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