| 宋 鹏,林 端,陈艳丽,魏日富,刘接威.HIF1-α和PCDGF在鼻咽癌诊断和预后评价中的临床价值研究[J].,2019,19(24):4789-4792 |
| HIF1-α和PCDGF在鼻咽癌诊断和预后评价中的临床价值研究 |
| The Clinical Value of HIF1- alpha and PCDGF in the Diagnosis and Treatment of Nasopharyngeal Carcinoma |
| 投稿时间：2019-08-05 修订日期：2019-08-28 |
| DOI：10.13241/j.cnki.pmb.2019.24.044 |
| 中文关键词: 鼻咽癌 缺氧诱导因子-1α 畸胎瘤细胞源性生长因子 预后 |
| 英文关键词: Nasopharyngeal carcinoma Hypoxic inducible factor -1?琢 Teratoma cell derived growth factor Prognosis |
| 基金项目:福建省自然科学基金项目（2014J01297） |
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| 中文摘要: |
| 摘要 目的：探讨鼻咽癌患者缺氧诱导因子-1α（HIF-1α）及畸胎瘤细胞源性生长因子（PCDGF）表达情况及与临床、预后关系。方法：选择我院2014年2月-2015年2月间诊治的鼻咽癌患者62例为观察组，健康志愿者40例为对照组，比较两组HIF-1α及PCDGF表达情况。观察鼻咽癌患者HIF-1α及PCDGF表达相关性，分析HIF-1α及PCDGF表达与预后关系。结果：观察组HIF-1α阳性表达率83.9%（52/62），PCDGF阳性表达率90.3%（56/62），均显著高于对照组的5.0 %（2/40）和7.5%（3/40），差异有统计学意义（x2=60.709，68.396，P＜0.05）。观察组中，T3及T4期、Ⅲ及Ⅳ期、有淋巴结转移者HIF-1α高表达、PCDGF高表达、HIF-1α和PCDGF高表达的比例明显高于T1及T2期，Ⅰ及Ⅱ期，无淋巴结转移者，差异有统计学意义（P＜0.05）。Spearman相关分析显示鼻咽癌患者HIF-1α与PCDGF表达呈正相关（r=0.856，P＜0.01）。 随访36周，患者整体生存率为65.7%。HIF-1α和PCDGF低表达、HIF-1α高表达、PCDGF高表达、HIF-1α和PCDGF高表达鼻咽癌患者生存率分别为87.5%、56.7%、67.9%和52.2，四组生存情况比较，差异有统计学意义（x2=4.433，P＜0.05）。结论：鼻咽癌患者HIF1-α和PCDGF具有高表达，其表达水平与患者临床、预后间关系密切。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of HIF-1α and PCDGF in patients with nasopharyngeal carcinoma and its relationship with clinical and prognosis. Methods: 62 patients with nasopharyngeal carcinoma who were diagnosed and treated in our hospital from February 2014 to February -2015 were selected as the observation group, and 40 healthy volunteers as the control group. The expressions of HIF-1α and PCDGF in two groups were compared. expression of HIF-1α and PCDGF in patients with nasopharyngeal carcinoma were observed, the relationship between the expression of HIF-1α alpha and PCDGF and the prognosis were analyzed. Results: The positive expression rate of HIF-1α in the observation group was 83.9% (52/62), and the positive expression rate of PCDGF was 90.3% (56/62), which was significantly higher than that in the control group 5% (2/40) and 7.5% (3/40), the difference was statistically significant (x2=60.709, 68.396, P<0.05). In the observation group, the proportion of high expression of HIF-1α and PCDGF and the high expression of HIF-1α and PCDGF in T3, T4, III and IV lymph node metastasis were significantly higher than those in T1 and T2 stage. There was significant difference between stage I and II, no lymph node metastasis (P<0.05). Spearman correlation analysis showed that the expression of HIF-1α was positively correlated with the expression of PCDGF in nasopharyngeal carcinoma (r=0.856, P<0.01). After 36 weeks of follow-up, the overall survival rate of the patients was 65.7%. The survival rates of patients with nasopharyngeal carcinoma were 87.5%, 56.7%, 67.9%, and 52.2, respectively. The survival rates of patients with nasopharyngeal carcinoma were significantly lower than those of patients with low expression of HIF-1α and PCDGF, high expression of HIF-1α and PCDGF, and high expression of HIF-1α and PCDGF. There was a statistically significant difference in survival between four groups (x2=4.433, P<0.05). Conclusion: HIF-1α and PCDGF are highly expressed in patients with nasopharyngeal carcinoma, and the expression level is closely related to the clinical and prognosis of the patients. |
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